rs888897

This is a downstream gene variant variant in the POC5 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

free cholesterol in very large HDL measurement

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele T

OR 0.05

p 7.0e-15

N 88,329

Large GWAS

European

cholesterol in very large HDL measurement

Allele T

OR 0.05

p 3.0e-14

N 88,329

Large GWAS

European

cholesteryl ester measurement

Allele T

OR 0.04

p 9.0e-14

N 88,329

Large GWAS

European

high density lipoprotein cholesterol measurement

Allele T

OR 0.04

p 1.0e-13

N 88,329

Large GWAS

European

total lipids in very large HDL measurement

Allele T

OR 0.04

p 2.0e-13

N 88,329

Large GWAS

European

About POC5

Involved in centriole elongation and negative regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]

View all POC5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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