rs9332891

This is a regulatory region variant variant in the MGST1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

triglyceride measurement

Kamiza AB et al. “Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.” Nature Communications 14(1):5403 (2023)
Allele G
OR 0.06
p 6.0e-16
N 125,000
Large GWAS
African American or Afro-Caribbean, Sub-Saharan African, African unspecified

total cholesterol measurement

Kamiza AB et al. “Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.” Nature Communications 14(1):5403 (2023)
Allele G
OR 0.07
p 4.0e-12
N 125,000
Large GWAS
African American or Afro-Caribbean, Sub-Saharan African, African unspecified

high density lipoprotein cholesterol measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.17
p 2.0e-30
N 578,125
Major Consortium StudyLarge GWAS
multi-ancestry
Kamiza AB et al. “Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry.” Nature Communications 14(1):5403 (2023)
Allele T
OR 0.06
p 3.0e-18
N 125,000
Large GWAS
African American or Afro-Caribbean, Sub-Saharan African, African unspecified
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele T
OR 0.13
p 8.0e-19
N 99,432
Large GWAS
African American or Afro-Caribbean, African unspecified

About MGST1

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

View all MGST1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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