rs9590974

This variant is located in the LRCH1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele A

OR —

p 1.0e-22

N 721,201

Large GWAS

multi-ancestry

PR interval

van Setten J et al. “PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.” Nature Communications 9(1):2904 (2018)

Allele C

OR 1.10

p 1.0e-19

N 92,340

Meta-analysisLarge GWAS

European

PR segment

Verweij N et al. “Genetic determinants of P wave duration and PR segment.” Circulation. Cardiovascular Genetics 7(4):475-81 (2014)

Allele A

OR 1.19

p 2.0e-8

N 16,468

Large GWAS

European

About LRCH1

This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]