APOA4

apolipoprotein A4

Summary

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

Known Variants116 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs534039500	11:116,691,054	C/T	—	—
rs1352011550	11:116,691,596	G/A	—	uncertain significance
rs1288845296	11:116,691,609	G/A	—	uncertain significance
rs140878274	11:116,691,621	G/T	—	likely benign
rs2134217444	11:116,691,629	T/C	—	uncertain significance
rs5110	11:116,691,634	C/A	missense variant	pathogenic
rs2540266502	11:116,691,654	C/T	—	uncertain significance
rs777231588	11:116,691,670	G/A	—	likely benign
rs675	11:116,691,675	T/C	—	likely benign
rs2540266622	11:116,691,695	T/G	—	uncertain significance
rs146353487	11:116,691,717	A/C	—	likely benign
rs147577451	11:116,691,720	T/A	—	uncertain significance
rs5109	11:116,691,766	C/A	—	benign
rs145761354	11:116,691,768	C/T	—	conflicting classifications of pathogenicity
rs545034382	11:116,691,769	G/A	—	likely benign
rs113263292	11:116,691,776	G/A	—	uncertain significance
rs1276295892	11:116,691,786	C/A	—	uncertain significance
rs769788860	11:116,691,805	T/C	—	likely benign
rs377752186	11:116,691,843	C/G	—	uncertain significance
rs373920026	11:116,691,844	G/A	—	likely benign
rs5108	11:116,691,855	C/G	—	uncertain significance
rs201021435	11:116,691,858	G/A	—	uncertain significance
rs150264487	11:116,691,861	G/T	—	uncertain significance
rs150624574	11:116,691,863	C/T	—	uncertain significance
rs781747963	11:116,691,864	G/A	—	uncertain significance
rs1941315652	11:116,691,873	C/G	—	uncertain significance
rs5107	11:116,691,886	C/T	—	benign
rs202147415	11:116,691,926	T/G	—	uncertain significance
rs5106	11:116,691,928	G/A	—	benign
rs1230372463	11:116,691,939	T/G	—	likely benign
rs1941316695	11:116,691,947	C/T	—	uncertain significance
rs751283052	11:116,691,951	G/A	—	uncertain significance
rs184083285	11:116,691,954	C/T	—	conflicting classifications of pathogenicity
rs146365840	11:116,691,955	G/A	—	benign
rs1366912241	11:116,691,960	C/T	—	uncertain significance
rs1042885652	11:116,691,961	G/A	—	likely benign
rs567844533	11:116,691,971	G/A	—	uncertain significance
rs2238008	11:116,691,983	C/T	—	uncertain significance
rs747989886	11:116,691,984	G/A	—	uncertain significance
rs5105	11:116,691,994	G/A	—	benign
rs1007036347	11:116,691,997	A/C	—	uncertain significance
rs576355748	11:116,692,005	A/C	—	uncertain significance
rs121909576	11:116,692,026	C/T	missense variant	benign
rs148724513	11:116,692,070	T/C	—	uncertain significance
rs1297222124	11:116,692,112	C/T	—	uncertain significance
rs780189684	11:116,692,113	G/A	—	uncertain significance
rs751787167	11:116,692,119	G/T	—	uncertain significance
rs983632449	11:116,692,128	C/T	—	uncertain significance
rs145184607	11:116,692,155	C/T	—	uncertain significance
rs140566468	11:116,692,175	C/T	—	uncertain significance
rs142050734	11:116,692,176	G/A	—	uncertain significance
rs145525856	11:116,692,204	G/T	—	likely benign
rs201861136	11:116,692,221	C/T	—	benign
rs148815297	11:116,692,224	C/T	—	uncertain significance
rs377729274	11:116,692,240	C/T	—	likely benign
rs1181852696	11:116,692,241	G/A	—	uncertain significance
rs751040950	11:116,692,254	T/C	—	uncertain significance
rs148364897	11:116,692,260	C/T	—	uncertain significance
rs1941323236	11:116,692,262	T/C	—	uncertain significance
rs200824051	11:116,692,266	C/T	—	likely benign
rs142295954	11:116,692,269	G/A	—	uncertain significance
rs1205081092	11:116,692,276	T/A	—	uncertain significance
rs371173298	11:116,692,291	T/C	—	likely benign
rs773002058	11:116,692,292	G/A	—	uncertain significance
rs12721043	11:116,692,293	C/T	—	uncertain significance
rs538954345	11:116,692,294	G/A	—	likely benign
rs767012223	11:116,692,295	T/C	—	uncertain significance
rs755709662	11:116,692,299	G/A	—	uncertain significance
rs746344058	11:116,692,313	C/A	—	conflicting classifications of pathogenicity
rs150633651	11:116,692,314	G/A	—	uncertain significance
rs768855419	11:116,692,323	C/T	—	uncertain significance
rs2234668	11:116,692,324	G/A	—	benign
rs5104	11:116,692,334	C/T	missense variant	benign
rs756971543	11:116,692,347	G/A	—	uncertain significance
rs1320283776	11:116,692,359	C/T	—	uncertain significance
rs748316209	11:116,692,370	A/G	—	uncertain significance
rs202096537	11:116,692,373	C/T	—	likely benign
rs774077750	11:116,692,374	G/T	—	uncertain significance
rs147610191	11:116,692,393	G/T	—	likely benign
rs546075642	11:116,692,401	C/T	—	uncertain significance
rs1446733564	11:116,692,411	G/C	—	uncertain significance
rs750749180	11:116,692,421	T/G	—	uncertain significance
rs755577773	11:116,692,440	G/A	—	uncertain significance
rs6413456	11:116,692,449	G/A	—	benign
rs775300231	11:116,692,481	A/C	—	uncertain significance
rs1350252050	11:116,692,482	G/A	—	likely benign
rs142176503	11:116,692,490	G/A	—	uncertain significance
rs561416907	11:116,692,505	C/T	—	uncertain significance
rs1941329497	11:116,692,517	T/C	—	uncertain significance
rs763552085	11:116,692,519	G/A	—	likely benign
rs569616428	11:116,692,520	G/A	—	uncertain significance
rs5103	11:116,692,552	G/A	—	benign
rs5101	11:116,692,558	G/A	—	benign
rs13306173	11:116,692,595	G/T	—	uncertain significance
rs5100	11:116,692,694	G/A	—	benign
rs5098	11:116,692,813	G/C	—	benign
rs5095	11:116,693,163	G/A	—	benign
rs5094	11:116,693,213	G/A	—	benign
rs2239013	11:116,693,353	C/T	—	benign
rs5093	11:116,693,354	G/A	—	benign

Showing 100 of 116 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.