ARHGEF15

Rho guanine nucleotide exchange factor 15

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

Known Variants505 total

rsidPosition (GRCh37)AllelesClassClinVar
rs136672981117:8,215,372C/T—likely benign
rs37035383817:8,215,373C/T—uncertain significance
rs75304386417:8,215,389C/T—uncertain significance
rs15048054017:8,215,391C/G—uncertain significance
rs74898683317:8,215,393C/G—likely benign
rs136640506717:8,215,394A/C—uncertain significance
rs37375172717:8,215,395C/G—uncertain significance
rs77530484917:8,215,396G/A—likely benign
rs20018788617:8,215,409C/T—uncertain significance
rs77339946917:8,215,410G/A—uncertain significance
rs13848422917:8,215,411G/A—likely benign
rs76644139217:8,215,418C/T—uncertain significance
rs148607692317:8,215,419G/A—uncertain significance
rs57785352217:8,215,420C/T—likely benign
rs75954348917:8,215,422C/T—uncertain significance
rs13790951917:8,215,424C/T—benign
rs75317230017:8,215,425G/A—uncertain significance
rs75704134717:8,215,430C/T—uncertain significance
rs77843874517:8,215,436C/T—uncertain significance
rs19966371417:8,215,437G/A—uncertain significance
rs76842500817:8,215,440C/T—uncertain significance
rs190466389117:8,215,447T/C—likely benign
rs156767361217:8,215,448G/T—uncertain significance
rs215163475417:8,215,449C/T—uncertain significance
rs135682584117:8,215,452A/G—uncertain significance
rs190466502217:8,215,457C/G—uncertain significance
rs215163477417:8,215,465T/C—likely benign
rs215163478217:8,215,470A/G—uncertain significance
rs77445518817:8,215,480C/T—likely benign
rs254392568617:8,215,488A/G—uncertain significance
rs76753086417:8,215,492A/G—likely benign
rs93883595117:8,215,499C/T—uncertain significance
rs76132553117:8,215,500G/A—uncertain significance
rs137674440917:8,215,531C/T—likely benign
rs140752571417:8,215,532A/T—uncertain significance
rs374465117:8,215,534C/T—benign
rs14937109417:8,215,535C/G—conflicting classifications of pathogenicity
rs190467222917:8,215,539T/A—uncertain significance
rs54292607617:8,215,540C/G—uncertain significance
rs74788567817:8,215,551C/T—uncertain significance
rs190467363617:8,215,554C/T—uncertain significance
rs123355202917:8,215,558T/G—likely benign
rs14470307617:8,215,561A/G—likely benign
rs77459879417:8,215,571C/T—uncertain significance
rs989084117:8,215,574C/T—benign
rs77218183317:8,215,585G/A—likely benign
rs120050354417:8,215,589C/T—uncertain significance
rs190467757517:8,215,591C/T—likely benign
rs130549430217:8,215,606C/T—likely benign
rs133992575617:8,215,609C/T—likely benign
rs77730008617:8,215,610C/T—uncertain significance
rs14135499417:8,215,612C/T—likely benign
rs14625770117:8,215,613G/A—conflicting classifications of pathogenicity
rs37534307117:8,215,623C/A—uncertain significance
rs76605811717:8,215,624T/C—likely benign
rs75450667717:8,215,644G/T—uncertain significance
rs190468685017:8,215,649C/T—uncertain significance
rs78106355517:8,215,651C/T—likely benign
rs254392667317:8,215,666G/A—likely benign
rs37564814517:8,215,670C/T—uncertain significance
rs77748492317:8,215,671G/A—uncertain significance
rs142985336317:8,215,672G/A—likely benign
rs14408059017:8,215,673C/T—uncertain significance
rs14648230417:8,215,674G/T—uncertain significance
rs13953248517:8,215,679G/A—conflicting classifications of pathogenicity
rs190469183817:8,215,688G/C—uncertain significance
rs77725074517:8,215,697C/T—uncertain significance
rs77338001217:8,215,700C/T—uncertain significance
rs76338602017:8,215,701G/A—uncertain significance
rs117956705817:8,215,702G/A—likely benign
rs124017131517:8,215,713C/A—uncertain significance
rs18540310817:8,215,714C/T—likely benign
rs75124442017:8,215,716C/G—uncertain significance
rs75607516617:8,215,725C/T—uncertain significance
rs75709857617:8,215,732G/T—likely benign
rs74727837517:8,215,743C/T—uncertain significance
rs14969214417:8,215,744G/A—likely benign
rs36854302717:8,215,745C/G—uncertain significance
rs11506500917:8,215,755C/A—uncertain significance
rs254392720717:8,215,761C/G—uncertain significance
rs159746070917:8,215,763G/A—uncertain significance
rs254392724117:8,215,769C/G—uncertain significance
rs20018898017:8,215,772G/A—uncertain significance
rs77396976617:8,215,793G/A—uncertain significance
rs75924325417:8,215,794C/A—uncertain significance
rs141705046617:8,215,797C/G—uncertain significance
rs37419587517:8,215,809G/A—uncertain significance
rs190470732817:8,215,813G/C—uncertain significance
rs215163544117:8,215,816G/A—likely benign
rs254392745417:8,215,824G/A—uncertain significance
rs254392748017:8,215,831A/C—uncertain significance
rs11607579417:8,215,833G/C—likely benign
rs75518195917:8,215,835G/A—uncertain significance
rs103164682517:8,215,847C/T—uncertain significance
rs106050005017:8,215,848G/A—uncertain significance
rs36803523417:8,215,856G/T—uncertain significance
rs55068756717:8,215,861A/G—likely benign
rs144068785817:8,215,866C/T—uncertain significance
rs14773631217:8,215,869C/T—conflicting classifications of pathogenicity
rs37288859117:8,215,870G/A—likely benign

Showing 100 of 505 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.