CLNK
cytokine dependent hematopoietic cell linker
Summary
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
Known Variants52 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs201603422 | 4:10,492,099 | G/A | — | uncertain significance |
| rs1234420437 | 4:10,492,114 | T/G | — | uncertain significance |
| rs376869195 | 4:10,492,116 | A/T | — | uncertain significance |
| rs762033179 | 4:10,492,158 | C/T | — | uncertain significance |
| rs189381725 | 4:10,492,187 | A/G | — | likely benign |
| rs1256668144 | 4:10,492,213 | T/A | — | uncertain significance |
| rs144945290 | 4:10,497,424 | G/T | — | — |
| rs749179971 | 4:10,502,882 | C/T | — | uncertain significance |
| rs768542855 | 4:10,502,883 | A/T | — | uncertain significance |
| rs2474347572 | 4:10,502,923 | C/T | — | uncertain significance |
| rs199925446 | 4:10,502,935 | C/T | — | uncertain significance |
| rs190441710 | 4:10,502,936 | G/A | — | likely benign |
| rs2903960 | 4:10,502,937 | T/G | — | benign |
| rs755722932 | 4:10,502,966 | A/G | — | likely benign |
| rs761640065 | 4:10,515,101 | C/G | — | uncertain significance |
| rs2474367872 | 4:10,515,182 | C/A | — | uncertain significance |
| rs761422989 | 4:10,515,200 | G/T | — | uncertain significance |
| rs1300301836 | 4:10,522,417 | C/G | — | uncertain significance |
| rs369927950 | 4:10,522,444 | G/A | — | likely benign |
| rs2108878 | 4:10,527,342 | C/A | — | — |
| rs183771991 | 4:10,527,468 | C/A | — | uncertain significance |
| rs189581402 | 4:10,527,472 | T/C | — | likely benign |
| rs369240819 | 4:10,527,474 | G/T | — | uncertain significance |
| rs765199111 | 4:10,542,169 | C/T | — | uncertain significance |
| rs374871726 | 4:10,542,180 | C/T | — | likely benign |
| rs776088269 | 4:10,542,196 | G/T | — | uncertain significance |
| rs766068690 | 4:10,542,226 | G/C | — | uncertain significance |
| rs200340688 | 4:10,543,893 | C/T | — | likely benign |
| rs555801267 | 4:10,566,326 | G/A | — | uncertain significance |
| rs768713482 | 4:10,566,335 | A/G | — | likely benign |
| rs114955321 | 4:10,566,489 | T/C | intron variant | — |
| rs375007582 | 4:10,567,659 | C/T | — | uncertain significance |
| rs369236380 | 4:10,567,712 | G/T | — | uncertain significance |
| rs746662018 | 4:10,573,384 | T/C | — | uncertain significance |
| rs75339413 | 4:10,582,604 | G/A | intron variant | — |
| rs774916302 | 4:10,586,568 | C/T | — | likely benign |
| rs61759824 | 4:10,586,571 | G/A | — | benign |
| rs371803390 | 4:10,599,660 | T/A | — | uncertain significance |
| rs148835649 | 4:10,607,008 | C/T | intron variant | — |
| rs113965639 | 4:10,609,824 | A/G | intron variant | — |
| rs532086090 | 4:10,623,496 | G/T | — | — |
| rs181296867 | 4:10,640,285 | C/T | intron variant | — |
| rs79488589 | 4:10,687,308 | A/T | upstream gene variant | — |
| rs4293777 | 4:10,716,939 | G/T | — | — |
| rs7437047 | 4:10,718,589 | G/A | intergenic variant | — |
| rs4269168 | 4:10,722,604 | C/T | — | — |
| rs10003123 | 4:10,723,258 | A/G | intergenic variant | — |
| rs7678867 | 4:10,726,059 | A/T | — | — |
| rs13103285 | 4:10,726,520 | C/G | — | — |
| rs16872571 | 4:10,726,853 | C/A | — | — |
| rs13142500 | 4:10,727,357 | T/C | intergenic variant | — |
| rs13109179 | 4:10,727,528 | G/A | intergenic variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.