DCPS
decapping enzyme, scavenger
Summary
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
Known Variants79 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs147755159 | 11:126,173,992 | C/T | — | uncertain significance |
| rs763469702 | 11:126,174,000 | G/C | — | uncertain significance |
| rs201108066 | 11:126,174,012 | C/A | — | uncertain significance |
| rs376410163 | 11:126,174,016 | A/G | — | uncertain significance |
| rs3740915 | 11:126,174,038 | C/T | — | benign |
| rs1951543240 | 11:126,174,046 | G/A | — | uncertain significance |
| rs147935593 | 11:126,174,062 | G/T | — | conflicting classifications of pathogenicity |
| rs931749425 | 11:126,174,111 | G/A | — | uncertain significance |
| rs1372075982 | 11:126,174,136 | G/T | — | uncertain significance |
| rs695029 | 11:126,174,164 | C/T | — | benign |
| rs2497258001 | 11:126,174,177 | G/T | — | likely pathogenic |
| rs1057519083 | 11:126,174,178 | T/C | — | pathogenic |
| rs746334180 | 11:126,174,180 | C/G | — | uncertain significance |
| rs149150998 | 11:126,176,490 | A/T | — | uncertain significance |
| rs144876585 | 11:126,176,503 | C/T | — | likely benign |
| rs138737928 | 11:126,176,523 | C/T | — | pathogenic |
| rs751972143 | 11:126,176,536 | G/A | — | likely benign |
| rs2497261667 | 11:126,176,546 | G/C | — | uncertain significance |
| rs637462 | 11:126,176,578 | G/A | — | benign |
| rs375853628 | 11:126,176,592 | A/G | — | uncertain significance |
| rs10547510 | 11:126,178,920 | T/G | — | — |
| rs3862627 | 11:126,181,592 | G/A | regulatory region variant | — |
| rs73017394 | 11:126,181,847 | C/T | — | — |
| rs73017399 | 11:126,186,312 | G/C | intron variant | — |
| rs1695739 | 11:126,196,175 | A/G | regulatory region variant | — |
| rs56207600 | 11:126,196,537 | G/A | intron variant | — |
| rs1794089 | 11:126,196,807 | G/A | intron variant | — |
| rs1951773571 | 11:126,200,276 | C/T | — | likely benign |
| rs651922 | 11:126,201,290 | A/G | intron variant | — |
| rs201550193 | 11:126,201,309 | C/T | — | uncertain significance |
| rs369643672 | 11:126,201,338 | C/T | — | uncertain significance |
| rs201132569 | 11:126,201,356 | C/T | — | uncertain significance |
| rs562800121 | 11:126,201,368 | C/T | — | uncertain significance |
| rs904572688 | 11:126,201,377 | C/T | — | likely pathogenic |
| rs775806454 | 11:126,201,384 | C/T | — | uncertain significance |
| rs779937365 | 11:126,201,424 | G/A | — | likely benign |
| rs190946640 | 11:126,201,433 | C/T | — | likely benign |
| rs34637393 | 11:126,208,188 | A/G | — | likely benign |
| rs762331988 | 11:126,208,193 | A/C | — | uncertain significance |
| rs772776014 | 11:126,208,199 | G/A | — | uncertain significance |
| rs147353126 | 11:126,208,208 | G/A | — | uncertain significance |
| rs751442511 | 11:126,208,215 | C/T | — | uncertain significance |
| rs188471699 | 11:126,208,216 | G/A | — | likely benign |
| rs556401323 | 11:126,208,220 | C/T | missense variant | pathogenic |
| rs139170738 | 11:126,208,232 | G/C | — | likely benign |
| rs143993571 | 11:126,208,236 | A/G | — | uncertain significance |
| rs2497300815 | 11:126,208,269 | C/G | — | uncertain significance |
| rs770528538 | 11:126,208,295 | G/A | — | pathogenic |
| rs572466350 | 11:126,208,299 | A/C | — | likely benign |
| rs75757016 | 11:126,212,022 | G/A | regulatory region variant | — |
| rs775194334 | 11:126,213,196 | A/G | — | likely benign |
| rs755203724 | 11:126,213,235 | C/T | — | uncertain significance |
| rs35836343 | 11:126,213,242 | G/A | — | likely benign |
| rs757830111 | 11:126,213,256 | C/T | — | uncertain significance |
| rs151074136 | 11:126,213,269 | C/T | — | uncertain significance |
| rs140997080 | 11:126,213,280 | C/T | — | uncertain significance |
| rs79514900 | 11:126,213,282 | G/A | — | benign |
| rs754246663 | 11:126,213,289 | A/G | — | uncertain significance |
| rs240536 | 11:126,213,395 | T/G | — | — |
| rs1455210854 | 11:126,215,246 | C/T | — | uncertain significance |
| rs146794173 | 11:126,215,263 | C/T | — | uncertain significance |
| rs140377449 | 11:126,215,285 | G/A | — | conflicting classifications of pathogenicity |
| rs752020530 | 11:126,215,294 | T/G | — | uncertain significance |
| rs142492066 | 11:126,215,298 | C/T | — | likely benign |
| rs368589401 | 11:126,215,349 | C/T | — | likely benign |
| rs768872827 | 11:126,215,350 | G/T | — | likely pathogenic |
| rs768778965 | 11:126,215,355 | C/T | — | likely benign |
| rs188923397 | 11:126,215,359 | G/A | — | uncertain significance |
| rs143135288 | 11:126,215,362 | T/G | — | likely benign |
| rs759966901 | 11:126,215,374 | C/T | — | uncertain significance |
| rs1951915017 | 11:126,215,391 | T/C | — | likely benign |
| rs148207687 | 11:126,215,400 | C/T | — | likely benign |
| rs1215363009 | 11:126,215,412 | G/C | — | uncertain significance |
| rs137941190 | 11:126,215,441 | C/G | missense variant | conflicting classifications of pathogenicity |
| rs143294413 | 11:126,215,448 | C/T | — | likely benign |
| rs201746166 | 11:126,215,466 | C/T | — | likely benign |
| rs150917728 | 11:126,215,471 | C/G | — | likely benign |
| rs139354381 | 11:126,215,507 | G/A | — | likely benign |
| rs17135401 | 11:126,218,773 | C/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.