DNM2

dynamin 2

Summary

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Known Variants1,012 total

rsidPosition (GRCh37)AllelesClassClinVar
rs88605413819:10,828,766G/T—uncertain significance
rs88605413919:10,828,797G/A—uncertain significance
rs96667207519:10,828,803C/T—uncertain significance
rs75359900419:10,828,900G/T—uncertain significance
rs251293121419:10,828,921G/T—uncertain significance
rs206881756619:10,828,922G/A—uncertain significance
rs137560671919:10,828,923G/A—uncertain significance
rs89029718819:10,828,926A/G—benign
rs120295539319:10,828,928C/T—uncertain significance
rs206881817419:10,828,934A/G—uncertain significance
rs100873139019:10,828,937G/C—uncertain significance
rs143513362319:10,828,938A/G—uncertain significance
rs124959667519:10,828,948C/T—likely benign
rs101481450119:10,828,949C/T—uncertain significance
rs251293133819:10,828,950C/T—uncertain significance
rs77950275819:10,828,951G/A—likely benign
rs206881883919:10,828,952C/G—uncertain significance
rs147986507719:10,828,955G/A—uncertain significance
rs214563763019:10,828,959A/G—uncertain significance
rs206881911819:10,828,962A/G—uncertain significance
rs214563765219:10,828,963A/G—likely benign
rs214563765719:10,828,964C/T—likely benign
rs74668861119:10,828,966G/A—likely benign
rs206881929419:10,828,972C/A—uncertain significance
rs159940252219:10,828,975C/T—likely benign
rs76344318219:10,828,981C/T—likely benign
rs214563773419:10,828,983C/G—uncertain significance
rs90621117419:10,828,984C/T—likely benign
rs121338612919:10,828,987C/A—likely benign
rs251293149019:10,828,988G/A—uncertain significance
rs206881992819:10,828,990C/T—likely benign
rs206881996619:10,828,995G/C—uncertain significance
rs206882002819:10,828,997T/G—uncertain significance
rs53460587819:10,828,999C/T—likely benign
rs77496266819:10,829,001A/T—uncertain significance
rs134494972619:10,829,006G/A—uncertain significance
rs75991954919:10,829,008C/G—uncertain significance
rs251293157619:10,829,009C/T—likely benign
rs214563784719:10,829,013C/T—uncertain significance
rs76772606719:10,829,014G/T—likely benign
rs251293161019:10,829,017G/A—likely benign
rs55274140219:10,829,020C/G—uncertain significance
rs76098017219:10,829,023T/A—likely benign
rs251293166219:10,829,027G/T—uncertain significance
rs126640678119:10,829,032C/A—likely benign
rs142517367019:10,829,044C/A—uncertain significance
rs75398992519:10,829,060C/T—conflicting classifications of pathogenicity
rs75712101219:10,829,067A/G—conflicting classifications of pathogenicity
rs129505439619:10,829,078C/G—uncertain significance
rs155569627219:10,829,082G/A—uncertain significance
rs206882198019:10,829,085C/T—uncertain significance
rs214563807719:10,829,086G/T—likely benign
rs251293191719:10,829,093G/A—likely benign
rs77854487119:10,829,094C/G—likely benign
rs11695628719:10,829,201C/A—likely benign
rs11330545019:10,829,307C/G—benign
rs7565437019:10,829,327G/C—likely benign
rs89208619:10,837,677G/Aintron variant—
rs1167165319:10,838,486G/T——
rs152974419:10,841,472T/Cintron variant—
rs1245987019:10,841,584C/Tintron variant—
rs14577878519:10,853,977C/Tintron variant—
rs6079408219:10,854,766G/Aintron variant—
rs1245994319:10,859,508G/Aregulatory region variant—
rs7799786019:10,862,501C/Gintron variant—
rs14243438519:10,866,689A/Gintron variant—
rs57346975019:10,870,398T/C—likely benign
rs90241890819:10,870,399C/T—likely benign
rs77933761019:10,870,401C/T—likely benign
rs74629922419:10,870,402C/T—likely benign
rs20073666919:10,870,405C/A—conflicting classifications of pathogenicity
rs74748449519:10,870,406C/A—likely benign
rs14831886019:10,870,407C/T—likely benign
rs76211103319:10,870,414G/C—uncertain significance
rs58777823419:10,870,416A/G—not provided
rs251309174619:10,870,420C/T—likely benign
rs77348070719:10,870,426C/T—likely benign
rs120398210419:10,870,427C/T—uncertain significance
rs76279523019:10,870,429C/T—likely benign
rs14955594219:10,870,435A/G—likely benign
rs93807532019:10,870,439A/G—uncertain significance
rs37149325819:10,870,441C/T—likely benign
rs14425039019:10,870,442G/A—conflicting classifications of pathogenicity
rs19257371719:10,870,448C/T—uncertain significance
rs156828380719:10,870,449G/A—uncertain significance
rs75208056619:10,870,452G/A—uncertain significance
rs214585570319:10,870,457C/T—uncertain significance
rs75564282519:10,870,460A/G—uncertain significance
rs87885414919:10,870,462T/C—conflicting classifications of pathogenicity
rs37532471419:10,870,465G/A—likely benign
rs36807530119:10,870,468G/A—conflicting classifications of pathogenicity
rs37201261419:10,870,471C/A—likely benign
rs214585575719:10,870,483A/C—uncertain significance
rs74754589419:10,870,486A/G—uncertain significance
rs142734647819:10,870,491A/G—uncertain significance
rs11319226919:10,870,493A/G—likely benign
rs36959632519:10,870,496G/T—likely benign
rs76990665919:10,870,497G/A—conflicting classifications of pathogenicity
rs14702699319:10,870,499A/C—conflicting classifications of pathogenicity
rs20127405619:10,870,500G/A—likely benign

Showing 100 of 1,012 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.