EIF4G3
eukaryotic translation initiation factor 4 gamma 3
Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Known Variants101 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2545787091 | 1:21,133,819 | T/C | — | uncertain significance |
| rs146669269 | 1:21,133,836 | T/C | — | likely benign |
| rs371347072 | 1:21,133,883 | C/T | — | uncertain significance |
| rs1282632284 | 1:21,133,984 | C/T | — | uncertain significance |
| rs755270163 | 1:21,137,303 | A/C | — | uncertain significance |
| rs2545876970 | 1:21,137,348 | C/T | — | uncertain significance |
| rs367637862 | 1:21,137,377 | G/C | — | uncertain significance |
| rs12126757 | 1:21,143,774 | A/C | — | — |
| rs138556551 | 1:21,143,942 | G/A | — | likely benign |
| rs770707628 | 1:21,143,950 | T/C | — | uncertain significance |
| rs2546113877 | 1:21,143,977 | T/C | — | uncertain significance |
| rs2061364839 | 1:21,144,003 | G/A | — | uncertain significance |
| rs375028441 | 1:21,144,010 | C/G | — | uncertain significance |
| rs777487330 | 1:21,144,012 | G/C | — | uncertain significance |
| rs748698088 | 1:21,144,013 | A/C | — | uncertain significance |
| rs770505543 | 1:21,144,017 | T/C | — | uncertain significance |
| rs2100382 | 1:21,146,422 | G/A | intron variant | — |
| rs760958641 | 1:21,154,145 | G/T | — | uncertain significance |
| rs2546413432 | 1:21,155,673 | T/C | — | uncertain significance |
| rs111817671 | 1:21,155,679 | A/G | — | likely benign |
| rs753853391 | 1:21,167,434 | T/G | — | uncertain significance |
| rs12042978 | 1:21,170,811 | T/C | downstream gene variant | — |
| rs2546819499 | 1:21,175,924 | T/G | — | uncertain significance |
| rs146529769 | 1:21,175,955 | T/C | — | uncertain significance |
| rs149032365 | 1:21,175,968 | C/A | — | uncertain significance |
| rs748818692 | 1:21,177,840 | T/C | — | uncertain significance |
| rs541460610 | 1:21,177,846 | C/T | — | uncertain significance |
| rs765794713 | 1:21,177,869 | G/C | — | uncertain significance |
| rs756948454 | 1:21,180,089 | G/A | — | uncertain significance |
| rs2546893658 | 1:21,180,126 | G/C | — | uncertain significance |
| rs141698528 | 1:21,183,955 | C/G | — | uncertain significance |
| rs2547100394 | 1:21,190,970 | T/G | — | uncertain significance |
| rs760997457 | 1:21,191,031 | G/C | — | uncertain significance |
| rs141989247 | 1:21,191,148 | G/A | — | uncertain significance |
| rs3816455 | 1:21,191,430 | A/T | — | — |
| rs193921047 | 1:21,191,668 | C/A | — | uncertain significance |
| rs201372176 | 1:21,191,740 | C/T | — | uncertain significance |
| rs2547350966 | 1:21,205,829 | C/T | — | uncertain significance |
| rs927375111 | 1:21,219,116 | A/G | — | uncertain significance |
| rs755498324 | 1:21,219,125 | C/T | — | uncertain significance |
| rs985917645 | 1:21,219,141 | G/A | — | uncertain significance |
| rs781618477 | 1:21,219,147 | T/A | — | uncertain significance |
| rs1344943080 | 1:21,219,150 | C/T | — | uncertain significance |
| rs2547556244 | 1:21,219,212 | A/G | — | uncertain significance |
| rs2547575746 | 1:21,220,012 | G/A | — | uncertain significance |
| rs965963565 | 1:21,220,077 | C/T | — | uncertain significance |
| rs372089216 | 1:21,220,089 | C/T | — | uncertain significance |
| rs140416357 | 1:21,220,108 | T/A | — | uncertain significance |
| rs1284535734 | 1:21,220,127 | G/C | — | uncertain significance |
| rs756112842 | 1:21,221,880 | C/T | — | uncertain significance |
| rs747274284 | 1:21,226,246 | G/C | — | uncertain significance |
| rs2547688384 | 1:21,226,255 | C/T | — | uncertain significance |
| rs529485745 | 1:21,226,331 | C/G | — | uncertain significance |
| rs935456960 | 1:21,226,346 | A/G | — | uncertain significance |
| rs748274356 | 1:21,226,371 | C/G | — | uncertain significance |
| rs150227207 | 1:21,226,402 | A/G | — | uncertain significance |
| rs1444879824 | 1:21,231,425 | G/A | — | uncertain significance |
| rs61781099 | 1:21,234,252 | T/C | — | — |
| rs10916900 | 1:21,239,059 | C/G | intron variant | — |
| rs61781106 | 1:21,258,204 | G/T | — | — |
| rs6698440 | 1:21,258,712 | C/T | regulatory region variant | — |
| rs2548426451 | 1:21,268,046 | T/G | — | uncertain significance |
| rs748539423 | 1:21,268,047 | C/A | — | uncertain significance |
| rs146540947 | 1:21,268,050 | C/T | — | uncertain significance |
| rs774669063 | 1:21,268,154 | G/A | — | uncertain significance |
| rs756951648 | 1:21,268,166 | G/C | — | uncertain significance |
| rs1455118062 | 1:21,268,259 | G/A | — | uncertain significance |
| rs370218455 | 1:21,268,299 | G/C | — | uncertain significance |
| rs765804000 | 1:21,268,319 | A/G | — | uncertain significance |
| rs1476285544 | 1:21,268,394 | A/T | — | uncertain significance |
| rs1424778247 | 1:21,268,410 | T/G | — | uncertain significance |
| rs753720688 | 1:21,268,454 | A/G | — | uncertain significance |
| rs1450827586 | 1:21,268,485 | C/T | — | uncertain significance |
| rs1352825098 | 1:21,268,548 | T/C | — | likely benign |
| rs760512131 | 1:21,268,584 | C/T | — | uncertain significance |
| rs1365597495 | 1:21,268,590 | T/C | — | likely benign |
| rs755408222 | 1:21,268,625 | G/A | — | uncertain significance |
| rs1062981 | 1:21,268,710 | C/T | — | likely benign |
| rs774079318 | 1:21,276,537 | G/C | — | uncertain significance |
| rs763355758 | 1:21,299,523 | G/A | — | uncertain significance |
| rs142257189 | 1:21,299,530 | G/T | — | uncertain significance |
| rs768014443 | 1:21,299,535 | G/A | — | uncertain significance |
| rs1183533925 | 1:21,299,568 | G/A | — | uncertain significance |
| rs6680486 | 1:21,302,774 | T/C | intron variant | — |
| rs761064914 | 1:21,306,896 | G/C | — | uncertain significance |
| rs147841357 | 1:21,306,910 | G/A | — | uncertain significance |
| rs1052935022 | 1:21,306,922 | G/A | — | uncertain significance |
| rs2077863904 | 1:21,307,638 | G/A | — | uncertain significance |
| rs765519866 | 1:21,307,639 | G/A | — | uncertain significance |
| rs368799178 | 1:21,307,677 | G/A | — | uncertain significance |
| rs774268372 | 1:21,329,207 | G/A | — | uncertain significance |
| rs10737455 | 1:21,337,702 | T/A | — | — |
| rs193208673 | 1:21,340,085 | C/G | — | — |
| rs187675206 | 1:21,346,237 | C/T | intron variant | — |
| rs957163 | 1:21,416,181 | G/A | — | — |
| rs11807193 | 1:21,420,617 | T/A | intron variant | — |
| rs10799682 | 1:21,424,030 | G/C | intron variant | — |
| rs7537072 | 1:21,434,533 | T/A | — | — |
| rs9426730 | 1:21,452,255 | A/T | intron variant | — |
| rs78649275 | 1:21,477,033 | T/C | regulatory region variant | — |
Showing 100 of 101 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.