ENPEP
glutamyl aminopeptidase
Summary
The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]
Known Variants65 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1304044358 | 4:111,397,607 | T/G | — | uncertain significance |
| rs1724103851 | 4:111,397,659 | G/A | — | uncertain significance |
| rs72890294 | 4:111,397,664 | A/G | — | benign |
| rs371103875 | 4:111,397,673 | C/T | — | uncertain significance |
| rs76248418 | 4:111,397,678 | C/T | — | benign |
| rs756976273 | 4:111,397,710 | G/A | — | uncertain significance |
| rs778285285 | 4:111,397,784 | G/A | — | uncertain significance |
| rs570596378 | 4:111,397,853 | G/T | — | uncertain significance |
| rs769223095 | 4:111,397,988 | A/G | — | uncertain significance |
| rs776005918 | 4:111,397,997 | C/T | — | uncertain significance |
| rs2476401710 | 4:111,398,065 | G/C | — | uncertain significance |
| rs201187378 | 4:111,398,075 | G/A | — | uncertain significance |
| rs540053490 | 4:111,398,139 | T/C | — | uncertain significance |
| rs1298528080 | 4:111,398,166 | C/T | — | uncertain significance |
| rs778078263 | 4:111,398,210 | G/A | — | likely benign |
| rs192667187 | 4:111,406,819 | T/C | intron variant | — |
| rs747854381 | 4:111,409,750 | G/C | — | uncertain significance |
| rs759359267 | 4:111,409,773 | G/T | — | uncertain significance |
| rs200540684 | 4:111,409,777 | C/T | — | uncertain significance |
| rs1724593200 | 4:111,409,825 | A/G | — | uncertain significance |
| rs373049379 | 4:111,409,837 | C/T | — | uncertain significance |
| rs6833731 | 4:111,410,482 | G/T | — | — |
| rs201316974 | 4:111,412,253 | C/T | — | uncertain significance |
| rs769868589 | 4:111,412,273 | G/C | — | uncertain significance |
| rs750087535 | 4:111,427,822 | G/T | — | uncertain significance |
| rs376732795 | 4:111,427,832 | G/A | — | uncertain significance |
| rs772467810 | 4:111,427,887 | C/T | — | uncertain significance |
| rs1160531203 | 4:111,430,868 | T/C | — | uncertain significance |
| rs2476473937 | 4:111,430,949 | G/A | — | uncertain significance |
| rs1471863865 | 4:111,430,959 | A/C | — | uncertain significance |
| rs34631771 | 4:111,430,963 | G/A | — | benign |
| rs2476475217 | 4:111,431,438 | A/C | — | uncertain significance |
| rs33966350 | 4:111,431,444 | G/A | stop gained | — |
| rs746607272 | 4:111,431,455 | G/C | — | uncertain significance |
| rs1725527735 | 4:111,431,479 | C/G | — | uncertain significance |
| rs777408475 | 4:111,434,661 | C/T | — | uncertain significance |
| rs138193515 | 4:111,434,683 | T/C | — | uncertain significance |
| rs777069598 | 4:111,436,537 | C/A | — | uncertain significance |
| rs761368948 | 4:111,441,409 | G/T | — | uncertain significance |
| rs143212590 | 4:111,441,426 | A/T | — | benign |
| rs764244016 | 4:111,441,445 | C/A | — | uncertain significance |
| rs544907084 | 4:111,441,470 | C/T | — | uncertain significance |
| rs2476504234 | 4:111,452,369 | C/G | — | uncertain significance |
| rs1726394668 | 4:111,452,401 | G/A | — | uncertain significance |
| rs940503293 | 4:111,452,418 | A/G | — | uncertain significance |
| rs756838444 | 4:111,463,909 | A/G | — | uncertain significance |
| rs149676891 | 4:111,463,981 | C/T | — | uncertain significance |
| rs142728357 | 4:111,464,190 | G/A | — | uncertain significance |
| rs200157627 | 4:111,464,211 | C/A | — | uncertain significance |
| rs1486870015 | 4:111,469,378 | C/A | — | uncertain significance |
| rs2476527330 | 4:111,469,426 | G/A | — | likely benign |
| rs750329312 | 4:111,469,430 | C/A | — | uncertain significance |
| rs781702190 | 4:111,469,450 | G/C | — | uncertain significance |
| rs2476529015 | 4:111,470,513 | A/C | — | uncertain significance |
| rs1337149476 | 4:111,470,745 | A/G | — | uncertain significance |
| rs1419583803 | 4:111,470,767 | A/G | — | uncertain significance |
| rs1364433327 | 4:111,470,782 | C/A | — | uncertain significance |
| rs2476530126 | 4:111,470,964 | A/G | — | uncertain significance |
| rs749892715 | 4:111,474,512 | A/G | — | uncertain significance |
| rs35812243 | 4:111,474,552 | C/A | — | benign |
| rs1727364917 | 4:111,474,589 | A/C | — | uncertain significance |
| rs533760687 | 4:111,474,596 | A/T | — | uncertain significance |
| rs867126200 | 4:111,474,604 | G/A | — | uncertain significance |
| rs1727611633 | 4:111,480,814 | A/G | — | uncertain significance |
| rs201213870 | 4:111,482,687 | G/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.