FN1

fibronectin 1

Summary

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]

Known Variants1,209 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs141470685	2:216,226,148	G/A	—	likely benign
rs369527578	2:216,226,285	C/T	—	conflicting classifications of pathogenicity
rs146924311	2:216,226,286	G/A	—	uncertain significance
rs778366340	2:216,226,304	C/G	—	uncertain significance
rs149294265	2:216,226,310	C/T	—	uncertain significance
rs757979640	2:216,226,311	A/T	—	uncertain significance
rs1366673139	2:216,226,319	G/C	—	uncertain significance
rs2053446114	2:216,226,333	A/G	—	likely pathogenic
rs574336108	2:216,226,344	A/C	—	benign
rs2106084754	2:216,226,346	C/T	—	uncertain significance
rs201573768	2:216,226,368	G/A	—	benign
rs116671379	2:216,226,379	T/C	—	likely benign
rs113068773	2:216,226,393	G/A	—	likely benign
rs114497844	2:216,226,630	G/C	—	likely benign
rs13394662	2:216,226,642	A/C	—	benign
rs768945288	2:216,226,672	T/C	—	likely benign
rs761996366	2:216,226,684	G/C	—	likely benign
rs2469092470	2:216,226,688	T/G	—	uncertain significance
rs2053549925	2:216,226,699	G/A	—	uncertain significance
rs759470429	2:216,226,708	T/C	—	likely benign
rs762328949	2:216,226,719	A/G	—	likely benign
rs751303604	2:216,226,744	G/A	—	uncertain significance
rs1232134807	2:216,226,746	A/G	—	likely benign
rs1028557072	2:216,226,755	G/A	—	likely benign
rs1559298353	2:216,226,757	G/A	—	uncertain significance
rs147460086	2:216,226,759	C/G	—	likely benign
rs756702314	2:216,226,769	C/T	—	uncertain significance
rs148505961	2:216,226,780	C/T	—	likely benign
rs371108916	2:216,226,786	T/C	—	uncertain significance
rs150636748	2:216,226,788	G/T	—	uncertain significance
rs2469094574	2:216,226,797	C/G	—	uncertain significance
rs1270873193	2:216,226,801	C/T	—	uncertain significance
rs762925169	2:216,226,812	T/A	—	likely benign
rs751109054	2:216,226,816	G/C	—	likely benign
rs73987859	2:216,226,953	G/A	—	benign
rs73089351	2:216,229,401	G/A	—	benign
rs2106137681	2:216,229,595	G/C	—	likely benign
rs2106137734	2:216,229,597	C/A	—	uncertain significance
rs149027846	2:216,229,602	C/T	—	uncertain significance
rs917976746	2:216,229,604	G/A	—	uncertain significance
rs2469156119	2:216,229,624	C/T	—	uncertain significance
rs1314375736	2:216,229,640	C/T	—	uncertain significance
rs749250118	2:216,229,641	G/A	—	likely benign
rs541854686	2:216,229,644	A/G	—	likely benign
rs2469156902	2:216,229,660	T/A	—	uncertain significance
rs561274088	2:216,229,670	C/T	—	uncertain significance
rs151174151	2:216,229,671	G/A	—	benign
rs754229346	2:216,229,684	C/G	—	uncertain significance
rs755450997	2:216,229,685	C/T	—	uncertain significance
rs752801107	2:216,229,688	C/G	—	uncertain significance
rs11651	2:216,229,692	A/G	—	benign
rs777807426	2:216,229,698	C/T	—	benign
rs747253191	2:216,229,699	G/A	—	uncertain significance
rs1280991130	2:216,229,722	C/G	—	likely benign
rs1222454624	2:216,229,727	C/G	—	likely benign
rs7579867	2:216,229,850	C/T	—	benign
rs112163563	2:216,230,031	T/G	—	likely benign
rs16853839	2:216,230,033	C/T	—	likely benign
rs7594168	2:216,230,081	T/C	—	benign
rs10498037	2:216,230,216	G/A	—	likely benign
rs112323657	2:216,230,227	C/T	—	likely pathogenic
rs1462548927	2:216,230,238	C/T	—	likely benign
rs768302524	2:216,230,241	G/A	—	likely benign
rs2469171146	2:216,230,253	T/C	—	likely benign
rs568449322	2:216,230,256	G/A	—	likely benign
rs777156270	2:216,230,295	T/A	—	likely benign
rs746475547	2:216,230,296	C/A	—	uncertain significance
rs770519404	2:216,230,301	A/T	—	likely benign
rs557049566	2:216,230,302	C/T	—	conflicting classifications of pathogenicity
rs759085028	2:216,230,303	G/A	—	uncertain significance
rs764525665	2:216,230,331	C/G	—	likely benign
rs2469172692	2:216,230,334	A/C	—	likely benign
rs767465132	2:216,230,338	T/C	—	conflicting classifications of pathogenicity
rs750707274	2:216,230,352	T/C	—	likely benign
rs2469173106	2:216,230,357	T/C	—	likely benign
rs778923755	2:216,230,360	G/A	—	likely benign
rs112179130	2:216,230,503	T/C	—	likely benign
rs2372540	2:216,230,533	T/A	—	benign
rs10581104	2:216,230,534	T/A	—	benign
rs2372541	2:216,230,627	C/T	—	benign
rs112504284	2:216,230,656	G/A	—	likely benign
rs112861030	2:216,232,272	A/G	—	likely benign
rs1250213	2:216,232,299	C/A	—	benign
rs147432901	2:216,232,363	T/C	—	likely benign
rs7568287	2:216,232,556	C/A	—	benign
rs750467436	2:216,232,569	A/G	—	likely benign
rs766654059	2:216,232,572	A/G	—	likely benign
rs186401678	2:216,232,579	T/C	—	benign
rs376751520	2:216,232,586	T/C	—	uncertain significance
rs758304187	2:216,232,588	G/C	—	uncertain significance
rs2106183202	2:216,232,595	C/T	—	uncertain significance
rs2106183242	2:216,232,600	C/T	—	uncertain significance
rs146149463	2:216,232,622	C/T	—	uncertain significance
rs868751626	2:216,232,640	G/C	—	uncertain significance
rs780756398	2:216,232,653	T/C	—	benign
rs2469224012	2:216,232,661	T/A	—	uncertain significance
rs545761792	2:216,232,681	A/G	—	likely benign
rs191304573	2:216,232,682	C/T	—	conflicting classifications of pathogenicity
rs372228808	2:216,232,683	G/A	—	likely benign
rs773443086	2:216,232,689	A/G	—	likely benign

Showing 100 of 1,209 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.