GADD45G
growth arrest and DNA damage inducible gamma
Summary
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Known Variants10 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2031968 | 9:92,218,310 | T/C | regulatory region variant | — |
| rs3138490 | 9:92,219,000 | T/G | — | — |
| rs3138493 | 9:92,219,260 | T/G | — | — |
| rs3138497 | 9:92,219,896 | C/G | — | — |
| rs141169302 | 9:92,220,036 | T/A | — | likely benign |
| rs2489877384 | 9:92,220,755 | A/G | — | uncertain significance |
| rs3138505 | 9:92,220,760 | G/A | — | benign |
| rs2489878126 | 9:92,220,925 | G/T | — | uncertain significance |
| rs144775138 | 9:92,220,957 | T/G | — | uncertain significance |
| rs5031028 | 9:92,221,004 | G/A | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.