H2AC7
H2A clustered histone 7
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Known Variants13 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs765273519 | 6:26,199,098 | T/G | — | uncertain significance |
| rs139406782 | 6:26,199,192 | G/C | — | uncertain significance |
| rs1367372191 | 6:26,199,261 | C/G | — | uncertain significance |
| rs1374620910 | 6:26,199,266 | T/G | — | uncertain significance |
| rs142347437 | 6:26,199,324 | C/A | — | uncertain significance |
| rs1765065104 | 6:26,199,381 | C/T | — | uncertain significance |
| rs2480772572 | 6:26,199,392 | G/A | — | uncertain significance |
| rs1225978609 | 6:26,199,398 | T/C | — | uncertain significance |
| rs1765065996 | 6:26,199,405 | C/T | — | uncertain significance |
| rs141689063 | 6:26,199,422 | G/T | — | uncertain significance |
| rs1246254970 | 6:26,199,462 | G/A | — | uncertain significance |
| rs34961555 | 6:26,199,903 | C/G | synonymous variant | — |
| rs806794 | 6:26,200,677 | A/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.