IRF2BP1
interferon regulatory factor 2 binding protein 1
Summary
Enables transcription corepressor activity and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11550348 | 19:46,387,344 | A/G | — | benign |
| rs2513817082 | 19:46,387,370 | C/T | — | uncertain significance |
| rs759673909 | 19:46,387,423 | G/T | — | uncertain significance |
| rs3745926 | 19:46,387,503 | T/C | — | benign |
| rs762974103 | 19:46,387,697 | G/C | — | uncertain significance |
| rs2513817487 | 19:46,387,771 | G/C | — | uncertain significance |
| rs60158447 | 19:46,387,792 | G/T | missense variant | — |
| rs547947358 | 19:46,387,834 | T/C | — | uncertain significance |
| rs1209230271 | 19:46,387,840 | T/G | — | uncertain significance |
| rs1365481536 | 19:46,387,886 | C/T | — | uncertain significance |
| rs777841092 | 19:46,387,909 | G/T | — | uncertain significance |
| rs1389841666 | 19:46,387,919 | G/A | — | uncertain significance |
| rs1480676165 | 19:46,388,249 | T/C | — | likely benign |
| rs140294780 | 19:46,388,473 | G/A | — | uncertain significance |
| rs1235183341 | 19:46,388,483 | C/T | — | uncertain significance |
| rs747575166 | 19:46,388,494 | G/A | — | uncertain significance |
| rs777094484 | 19:46,388,521 | A/G | — | uncertain significance |
| rs753804128 | 19:46,388,593 | G/A | — | uncertain significance |
| rs1328462931 | 19:46,388,678 | C/T | — | uncertain significance |
| rs1419033363 | 19:46,388,693 | T/A | — | uncertain significance |
| rs1967044166 | 19:46,388,775 | C/G | — | uncertain significance |
| rs1028757167 | 19:46,388,776 | T/A | — | uncertain significance |
| rs766189216 | 19:46,388,791 | G/A | — | uncertain significance |
| rs1402187571 | 19:46,388,825 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.