KCNK3

potassium two pore domain channel subfamily K member 3

Summary

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

Known Variants182 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1275988	2:26,914,364	C/T	upstream gene variant	—
rs868836533	2:26,915,616	G/C	—	likely benign
rs12476527	2:26,915,624	G/T	—	benign
rs756684255	2:26,915,742	C/A	—	likely benign
rs1226314697	2:26,915,760	T/C	—	uncertain significance
rs1085307438	2:26,915,766	C/A	missense variant	pathogenic
rs535800063	2:26,915,767	G/C	—	benign
rs1670187610	2:26,915,771	G/A	—	uncertain significance
rs1447822219	2:26,915,772	C/A	—	uncertain significance
rs1490844068	2:26,915,782	G/A	—	likely benign
rs779891608	2:26,915,783	T/G	—	uncertain significance
rs2465285110	2:26,915,826	C/T	—	uncertain significance
rs770047414	2:26,915,836	G/C	—	likely benign
rs528661453	2:26,915,842	C/G	—	likely benign
rs1553383771	2:26,915,843	G/A	—	uncertain significance
rs2465285130	2:26,915,845	G/T	—	uncertain significance
rs1010960867	2:26,915,851	C/T	—	likely benign
rs1022064324	2:26,915,863	G/A	—	likely benign
rs776045749	2:26,915,890	G/A	—	likely benign
rs761090652	2:26,915,895	G/T	—	uncertain significance
rs1336188397	2:26,915,910	A/T	—	uncertain significance
rs753384871	2:26,915,915	G/A	—	uncertain significance
rs2465285223	2:26,915,921	G/C	—	uncertain significance
rs1025063325	2:26,915,945	C/T	—	uncertain significance
rs1185841087	2:26,915,956	G/T	—	likely benign
rs746843850	2:26,915,963	G/T	—	uncertain significance
rs2148251805	2:26,915,987	G/A	—	uncertain significance
rs1334466981	2:26,915,992	C/T	—	likely benign
rs1670190683	2:26,915,997	A/G	—	uncertain significance
rs1572598853	2:26,916,018	C/T	—	uncertain significance
rs2148251817	2:26,916,022	C/A	—	likely benign
rs1407972554	2:26,916,031	C/T	—	uncertain significance
rs369557396	2:26,916,032	G/T	—	likely benign
rs745920220	2:26,916,044	G/C	—	likely benign
rs768843323	2:26,916,046	G/A	—	likely benign
rs111740015	2:26,916,140	C/G	—	benign
rs35021474	2:26,916,844	C/G	intron variant	—
rs1314982	2:26,922,062	G/A	intron variant	—
rs1275978	2:26,923,095	C/T	intron variant	—
rs1275979	2:26,923,568	T/C	intron variant	—
rs147815385	2:26,923,658	C/T	intron variant	—
rs13394970	2:26,929,282	T/G	intron variant	—
rs2586886	2:26,932,031	C/G	—	—
rs1275923	2:26,932,796	C/T	intron variant	—
rs4665896	2:26,943,117	C/T	regulatory region variant	—
rs1447941011	2:26,950,526	T/A	—	likely benign
rs398123040	2:26,950,540	G/A	missense variant	pathogenic
rs143689341	2:26,950,545	C/T	—	likely benign
rs199957242	2:26,950,560	G/T	—	likely benign
rs1572616044	2:26,950,574	T/G	—	uncertain significance
rs2148038235	2:26,950,575	G/T	—	likely benign
rs767471086	2:26,950,593	G/A	—	likely benign
rs1663449720	2:26,950,614	G/A	—	likely benign
rs1553387422	2:26,950,616	T/C	—	likely pathogenic
rs61736657	2:26,950,617	C/T	—	likely benign
rs2148038286	2:26,950,637	G/A	—	uncertain significance
rs1663450536	2:26,950,649	A/G	—	pathogenic
rs747071763	2:26,950,665	C/T	—	benign
rs151228365	2:26,950,674	C/A	—	likely benign
rs549690582	2:26,950,676	G/A	—	uncertain significance
rs1248166790	2:26,950,689	G/T	—	likely benign
rs770558129	2:26,950,690	C/T	—	likely benign
rs773900452	2:26,950,699	C/A	—	likely benign
rs112956865	2:26,950,707	C/T	—	likely benign
rs2148038353	2:26,950,710	C/T	—	likely benign
rs2465323845	2:26,950,711	G/A	—	likely benign
rs763917048	2:26,950,716	C/T	—	likely benign
rs1359969792	2:26,950,731	G/T	—	likely benign
rs199970334	2:26,950,734	C/G	—	likely benign
rs540879740	2:26,950,737	C/T	—	likely benign
rs2148038390	2:26,950,739	G/A	—	uncertain significance
rs781570652	2:26,950,752	C/T	—	likely benign
rs1053068137	2:26,950,755	C/G	—	uncertain significance
rs748629731	2:26,950,761	G/A	—	likely benign
rs756202737	2:26,950,782	C/G	—	likely benign
rs1169009672	2:26,950,786	T/C	—	uncertain significance
rs398123042	2:26,950,795	G/A	missense variant	pathogenic
rs1558604738	2:26,950,798	C/T	—	uncertain significance
rs2465324046	2:26,950,818	C/T	—	likely benign
rs398123043	2:26,950,826	A/G	missense variant	pathogenic
rs760730673	2:26,950,830	C/T	—	likely benign
rs2465324094	2:26,950,858	G/C	—	pathogenic
rs398123039	2:26,950,859	G/A	missense variant	pathogenic
rs1663455707	2:26,950,861	G/A	—	uncertain significance
rs536179160	2:26,950,869	G/A	—	conflicting classifications of pathogenicity
rs199986870	2:26,950,872	G/A	—	likely benign
rs2465324154	2:26,950,883	A/G	—	likely benign
rs2148038490	2:26,950,887	G/A	—	likely benign
rs1403377581	2:26,950,891	C/T	—	likely benign
rs34292597	2:26,950,905	G/T	—	likely benign
rs398123041	2:26,950,912	G/C	missense variant	pathogenic
rs1421695861	2:26,950,957	G/C	—	uncertain significance
rs2465324303	2:26,950,960	G/A	—	uncertain significance
rs2148038552	2:26,950,965	C/T	—	likely benign
rs2148038555	2:26,950,967	T/C	—	uncertain significance
rs2148038557	2:26,950,972	C/T	—	uncertain significance
rs879213487	2:26,950,992	G/A	—	uncertain significance
rs1429533481	2:26,950,995	C/T	—	likely benign
rs1015646363	2:26,950,997	T/C	—	uncertain significance
rs1363361765	2:26,951,001	C/T	—	likely benign

Showing 100 of 182 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.