rs13394970

This is a intron variant variant in the KCNK3 gene.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

diastolic blood pressure

Pozarickij A et al. “Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.” Nature Communications 15(1):6265 (2024)

Allele T

OR 0.61

p 5.0e-22

N 100,453

Large GWAS

East Asian

non-high density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele T

OR 0.01

p 5.0e-13

N 1,320,016

Large GWAS

European

total cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele G

OR 0.01

p 1.0e-12

N 1,320,016

Large GWAS

European

Agents acting on the renin-angiotensin system use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.06

p 1.0e-10

N 178,726

Large GWAS

East Asian

apolipoprotein B measurement

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele T

OR 0.01

p 2.0e-10

N 439,214

Large GWAS

European

hypertension

Kim YS et al. “Lifestage Sex-Specific Genetic Effects on Metabolic Disorders in an Adult Population in Korea: The Korean Genome and Epidemiology Study.” International Journal of Molecular Sciences 23(19) (2022)

Allele G

OR 0.90

p 4.0e-10

N 50,808

Large GWAS

East Asian

right ventricular systolic volume measurement

Schmidt AF et al. “Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.” Science Advances 9(17):eadd4984 (2023)

Allele T

OR —

p 5.0e-10

N 35,928

Large GWAS

European

low density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele G

OR 0.01

p 8.0e-9

N 1,320,016

Large GWAS

European

fatty acid amount

Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)

Allele T

OR —

p 1.0e-8

N 239,268

Large GWAS

European

About KCNK3

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

rs13394970

GWAS Catalog Trait Associations (9)

diastolic blood pressure

non-high density lipoprotein cholesterol measurement

total cholesterol measurement

Agents acting on the renin-angiotensin system use measurement

apolipoprotein B measurement

hypertension

right ventricular systolic volume measurement

low density lipoprotein cholesterol measurement

fatty acid amount

About KCNK3

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