KDM4B

lysine demethylase 4B

Summary

Enables histone H3K36 demethylase activity and histone H3K9me2/H3K9me3 demethylase activity. Predicted to be involved in brain development; chromatin remodeling; and regulation of gene expression. Located in cytosol and nucleoplasm. Implicated in autosomal dominant intellectual developmental disorder 65; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants201 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs58324296	19:4,969,199	A/C	regulatory region variant	—
rs9676789	19:4,973,852	A/G	—	—
rs9676981	19:4,973,878	T/C	intron variant	—
rs388022	19:4,978,203	T/G	—	—
rs117864137	19:4,983,304	A/G	intron variant	—
rs197152	19:4,985,300	G/A	intron variant	—
rs11881751	19:4,997,420	G/A	intron variant	—
rs62647699	19:4,999,932	A/G	intron variant	—
rs75792932	19:5,006,218	C/T	intron variant	—
rs10420726	19:5,007,681	C/T	intron variant	—
rs34889187	19:5,018,959	G/T	—	—
rs263063	19:5,022,604	T/A	—	—
rs2512188593	19:5,032,903	T/C	—	uncertain significance
rs750066645	19:5,032,927	A/G	—	uncertain significance
rs1181437406	19:5,032,952	G/A	—	likely benign
rs781760371	19:5,032,956	C/T	—	uncertain significance
rs748282025	19:5,032,957	G/A	—	uncertain significance
rs769976056	19:5,032,966	T/C	—	uncertain significance
rs11667206	19:5,032,987	A/G	—	uncertain significance
rs2512189106	19:5,032,993	A/G	—	uncertain significance
rs10411421	19:5,036,564	G/A	intron variant	—
rs56249413	19:5,036,730	G/A	intron variant	—
rs2512225126	19:5,039,849	C/G	—	uncertain significance
rs1383961665	19:5,039,872	C/T	—	uncertain significance
rs1599476531	19:5,039,874	C/T	—	uncertain significance
rs141838567	19:5,039,900	C/T	—	likely benign
rs779243475	19:5,039,912	G/A	—	likely benign
rs746110307	19:5,039,914	C/T	—	uncertain significance
rs1395918076	19:5,039,993	C/T	—	conflicting classifications of pathogenicity
rs2036754505	19:5,040,018	G/A	—	uncertain significance
rs150616189	19:5,041,161	C/T	—	uncertain significance
rs2240678	19:5,041,178	C/T	—	benign
rs2512234473	19:5,041,180	A/G	—	uncertain significance
rs2145667461	19:5,041,189	G/A	—	uncertain significance
rs1432451428	19:5,041,263	G/A	—	pathogenic
rs2512235227	19:5,041,267	G/T	—	uncertain significance
rs35556519	19:5,047,483	A/G	—	likely benign
rs2037064259	19:5,047,485	A/G	—	uncertain significance
rs2037064539	19:5,047,490	G/A	—	uncertain significance
rs1470477522	19:5,047,508	G/A	—	uncertain significance
rs142693998	19:5,047,549	C/T	—	likely benign
rs780782889	19:5,047,550	G/A	—	uncertain significance
rs2512269596	19:5,047,573	C/G	—	uncertain significance
rs144944237	19:5,047,574	A/G	—	uncertain significance
rs2512269791	19:5,047,643	A/G	—	uncertain significance
rs2620818	19:5,047,691	A/G	—	benign
rs2613765	19:5,066,330	G/C	—	—
rs2145822607	19:5,071,053	T/C	—	pathogenic
rs151146933	19:5,071,058	C/T	—	likely pathogenic
rs28478353	19:5,071,460	G/A	intron variant	—
rs35218861	19:5,074,003	C/G	—	—
rs2512400956	19:5,077,461	T/A	—	uncertain significance
rs779100416	19:5,077,479	C/G	—	uncertain significance
rs11673509	19:5,080,647	C/G	—	—
rs138157752	19:5,082,388	A/T	—	uncertain significance
rs769783719	19:5,082,392	C/T	—	likely benign
rs377665250	19:5,082,393	G/A	—	uncertain significance
rs2145871774	19:5,082,400	T/C	—	uncertain significance
rs1267828116	19:5,082,444	G/A	—	uncertain significance
rs2512424215	19:5,082,468	A/G	—	uncertain significance
rs2038329308	19:5,082,474	G/A	—	uncertain significance
rs142811030	19:5,082,479	C/A	—	benign
rs34298574	19:5,082,497	C/T	—	benign
rs144268009	19:5,084,640	A/G	intron variant	—
rs2512536876	19:5,110,664	C/T	—	uncertain significance
rs2512536901	19:5,110,667	T/C	—	uncertain significance
rs140196276	19:5,110,704	C/T	—	likely benign
rs1466512977	19:5,110,747	A/G	—	uncertain significance
rs577391084	19:5,110,751	G/A	—	uncertain significance
rs151101183	19:5,110,757	C/T	—	uncertain significance
rs745995845	19:5,110,766	C/G	—	likely benign
rs139508576	19:5,110,773	C/T	—	likely benign
rs775667638	19:5,110,774	G/A	—	uncertain significance
rs2512537652	19:5,110,786	T/C	—	uncertain significance
rs2613739	19:5,110,794	G/A	—	benign
rs774247462	19:5,110,798	C/T	—	uncertain significance
rs1332206376	19:5,110,819	C/T	—	uncertain significance
rs146701782	19:5,110,828	A/G	—	uncertain significance
rs183356963	19:5,111,440	G/A	—	likely benign
rs2039143931	19:5,111,466	C/T	—	uncertain significance
rs368919809	19:5,111,468	G/A	—	likely benign
rs776061116	19:5,111,524	A/C	—	likely benign
rs370076937	19:5,111,819	G/C	—	uncertain significance
rs2146018043	19:5,119,683	C/T	—	likely pathogenic
rs908607176	19:5,119,699	A/C	—	uncertain significance
rs2512571298	19:5,119,728	G/A	—	uncertain significance
rs374489612	19:5,119,732	C/T	—	uncertain significance
rs368897143	19:5,119,744	C/A	—	conflicting classifications of pathogenicity
rs759014600	19:5,119,789	C/T	—	uncertain significance
rs2146018826	19:5,119,835	A/G	—	likely benign
rs936726492	19:5,119,839	G/A	—	uncertain significance
rs908556179	19:5,119,842	C/T	—	uncertain significance
rs779536081	19:5,119,843	G/A	—	uncertain significance
rs112383703	19:5,119,857	G/A	—	likely benign
rs780139122	19:5,119,871	C/T	—	likely benign
rs556074023	19:5,123,509	C/T	—	likely benign
rs531485431	19:5,123,539	T/C	—	likely benign
rs2512130849	19:5,131,086	G/A	—	likely pathogenic
rs115799672	19:5,131,091	C/T	—	benign
rs2512130867	19:5,131,092	G/A	—	uncertain significance

Showing 100 of 201 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.