KLRG1

killer cell lectin like receptor G1

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]

Known Variants15 total

rsidPosition (GRCh37)AllelesClassClinVar
rs20204635312:9,119,414A/T
rs730138112:9,123,932T/A
rs731494212:9,127,604A/C
rs1282798812:9,130,287A/T
rs8001739412:9,133,256A/Gintron variant
rs20089525712:9,142,305A/Guncertain significance
rs14844678012:9,144,883T/Cuncertain significance
rs76657392612:9,147,760G/Alikely benign
rs53477208612:9,147,868C/Tuncertain significance
rs74581902912:9,161,598G/Auncertain significance
rs76987416512:9,161,599C/Alikely benign
rs76898484112:9,161,616C/Auncertain significance
rs194758348412:9,162,119A/Guncertain significance
rs180567212:9,163,177A/Gbenign
rs11271207512:9,281,600A/G

Gene information from NCBI Gene. Variant classifications from ClinVar.