LRP1B

LDL receptor related protein 1B

Summary

This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]

Known Variants388 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs142353749	2:140,990,756	T/C	—	likely benign
rs1020304835	2:140,990,810	C/T	—	uncertain significance
rs140358724	2:140,990,868	C/T	—	likely benign
rs137949946	2:140,992,345	C/A	—	benign
rs78797806	2:140,992,347	T/C	—	benign
rs749162634	2:140,995,792	T/G	—	uncertain significance
rs2104881686	2:140,995,804	G/C	—	uncertain significance
rs777607055	2:140,997,014	C/T	—	uncertain significance
rs149112195	2:140,997,045	C/A	—	uncertain significance
rs895238849	2:140,997,086	A/G	—	uncertain significance
rs779399200	2:141,027,821	G/A	—	uncertain significance
rs150457308	2:141,032,006	C/A	—	uncertain significance
rs149644677	2:141,032,021	T/A	—	likely benign
rs2104952122	2:141,032,060	C/T	—	uncertain significance
rs200243152	2:141,032,086	C/T	—	uncertain significance
rs148187862	2:141,032,087	G/C	—	uncertain significance
rs1386356	2:141,032,088	C/T	—	benign
rs758802987	2:141,032,165	C/T	—	uncertain significance
rs751944741	2:141,032,167	T/C	—	uncertain significance
rs35902922	2:141,043,537	T/C	intron variant	—
rs143745437	2:141,055,396	G/C	—	likely benign
rs767939250	2:141,055,499	G/T	—	uncertain significance
rs149487197	2:141,055,516	T/G	—	likely benign
rs201590927	2:141,055,541	A/G	—	likely benign
rs17386226	2:141,072,519	C/G	—	likely benign
rs374934851	2:141,072,557	T/C	—	uncertain significance
rs1684462080	2:141,072,612	C/G	—	uncertain significance
rs2105053153	2:141,079,540	C/T	—	uncertain significance
rs1311777661	2:141,079,595	T/C	—	uncertain significance
rs147162004	2:141,079,617	G/A	—	benign
rs2105058875	2:141,081,464	T/G	—	uncertain significance
rs2467420047	2:141,081,474	T/C	—	uncertain significance
rs139908062	2:141,081,479	C/T	—	likely benign
rs771980814	2:141,081,501	T/C	—	uncertain significance
rs766446368	2:141,081,535	T/G	—	likely benign
rs541877634	2:141,081,537	A/C	—	likely benign
rs146863547	2:141,081,613	G/A	—	benign
rs137873952	2:141,081,616	C/T	—	likely benign
rs2467426571	2:141,083,418	T/C	—	likely pathogenic
rs2105083124	2:141,092,034	G/C	—	uncertain significance
rs79879036	2:141,092,084	T/G	—	likely benign
rs1681046895	2:141,093,191	T/C	—	uncertain significance
rs150957163	2:141,093,253	G/A	—	likely benign
rs139868893	2:141,093,334	G/A	—	uncertain significance
rs1348817923	2:141,093,359	C/T	—	uncertain significance
rs1174870911	2:141,108,411	T/C	—	likely benign
rs770860780	2:141,108,425	C/T	—	uncertain significance
rs139778530	2:141,108,442	G/C	—	likely benign
rs772310658	2:141,108,451	A/G	—	uncertain significance
rs371627395	2:141,108,498	A/T	—	uncertain significance
rs369651702	2:141,108,530	C/T	—	uncertain significance
rs16843826	2:141,108,531	G/A	—	benign
rs182361356	2:141,110,570	C/T	—	uncertain significance
rs185628679	2:141,113,924	G/T	—	benign
rs190269691	2:141,113,930	C/T	—	benign
rs138237325	2:141,113,994	G/A	—	benign
rs756410307	2:141,114,037	C/T	—	uncertain significance
rs35757222	2:141,115,582	G/A	—	benign
rs150879175	2:141,116,420	C/T	—	likely benign
rs35546150	2:141,116,447	G/T	—	benign
rs138052993	2:141,116,451	C/T	—	likely benign
rs145962775	2:141,116,461	C/T	—	uncertain significance
rs753869074	2:141,122,287	C/T	—	uncertain significance
rs757305272	2:141,122,289	C/A	—	uncertain significance
rs537284372	2:141,122,308	G/C	—	uncertain significance
rs193278497	2:141,122,343	A/T	—	uncertain significance
rs749286394	2:141,128,273	C/A	—	likely benign
rs773871940	2:141,128,281	C/A	—	likely benign
rs372614781	2:141,128,400	C/A	—	likely benign
rs72990625	2:141,128,758	C/G	—	likely benign
rs144347127	2:141,128,774	A/G	—	conflicting classifications of pathogenicity
rs76554185	2:141,128,779	C/G	—	benign
rs780664085	2:141,128,791	A/G	—	uncertain significance
rs763615773	2:141,128,819	C/T	—	uncertain significance
rs752964745	2:141,128,833	C/T	—	uncertain significance
rs752198878	2:141,130,598	C/T	—	uncertain significance
rs1683063421	2:141,130,658	C/T	—	uncertain significance
rs145915063	2:141,130,669	C/T	—	likely benign
rs16843864	2:141,130,695	C/T	—	benign
rs2467563527	2:141,135,776	A/C	—	uncertain significance
rs1273937503	2:141,135,796	T/C	—	uncertain significance
rs2105183217	2:141,135,840	G/A	—	uncertain significance
rs368178283	2:141,143,482	T/C	—	uncertain significance
rs752743011	2:141,143,523	G/A	—	likely benign
rs144998818	2:141,200,082	C/T	—	benign
rs375190223	2:141,200,086	G/A	—	likely benign
rs909484729	2:141,200,186	T/C	—	uncertain significance
rs375055324	2:141,201,951	T/G	—	uncertain significance
rs2467733075	2:141,201,999	T/C	—	likely benign
rs193920865	2:141,202,006	C/G	—	uncertain significance
rs2105305262	2:141,202,240	T/C	—	uncertain significance
rs768863268	2:141,214,032	C/T	—	uncertain significance
rs2467762775	2:141,214,041	T/C	—	uncertain significance
rs150113526	2:141,214,100	T/C	—	uncertain significance
rs2467766741	2:141,215,089	A/T	—	likely benign
rs2105324401	2:141,215,209	C/T	—	uncertain significance
rs72899866	2:141,226,309	T/C	—	—
rs567834250	2:141,232,776	G/A	—	uncertain significance
rs72899872	2:141,232,800	T/C	—	benign
rs1687923684	2:141,232,808	C/T	—	uncertain significance

Showing 100 of 388 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.