LRRK2

leucine rich repeat kinase 2

Summary

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

Known Variants2,927 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1087822612:40,617,692G/Cupstream gene variant—
rs5862129812:40,618,686T/C—benign
rs11515019712:40,618,705G/A—likely benign
rs11264365712:40,618,810G/C—likely benign
rs95751152512:40,618,843C/T—uncertain significance
rs142291099412:40,618,860C/A—conflicting classifications of pathogenicity
rs76523244812:40,618,890G/A—likely benign
rs194079969912:40,618,942T/C—likely benign
rs194080004412:40,618,950G/A—uncertain significance
rs249932921412:40,618,951T/C—likely benign
rs249932925612:40,618,954G/T—uncertain significance
rs98163225012:40,618,955G/A—uncertain significance
rs28186504012:40,618,961G/A—uncertain significance
rs75967001212:40,618,962A/C—uncertain significance
rs249932953812:40,618,965A/C—uncertain significance
rs194080176512:40,618,966G/A—likely benign
rs249932958612:40,618,969C/G—uncertain significance
rs249932960912:40,618,970G/A—uncertain significance
rs77540745812:40,618,972G/C—uncertain significance
rs14239962312:40,618,978T/C—likely benign
rs194080308612:40,618,982A/C—uncertain significance
rs76048904812:40,618,984G/A—likely benign
rs76628269312:40,618,987G/A—likely benign
rs194080347212:40,618,993A/G—uncertain significance
rs249933005412:40,618,996C/A—likely benign
rs15128350712:40,618,999G/C—uncertain significance
rs75457538912:40,619,000C/T—likely benign
rs77867829812:40,619,004A/G—uncertain significance
rs249933024612:40,619,007A/G—uncertain significance
rs159212454212:40,619,008T/C—likely benign
rs75211968412:40,619,009G/A—uncertain significance
rs147035883712:40,619,020A/G—likely benign
rs75793788212:40,619,027A/T—uncertain significance
rs249933060112:40,619,029A/G—uncertain significance
rs249933062812:40,619,033A/T—uncertain significance
rs117916356412:40,619,035G/C—conflicting classifications of pathogenicity
rs77820730612:40,619,036C/T—likely benign
rs124577339412:40,619,044A/G—likely benign
rs249933083612:40,619,045A/G—uncertain significance
rs159212461012:40,619,047C/A—likely benign
rs249933093612:40,619,049T/C—uncertain significance
rs249933099312:40,619,052A/G—uncertain significance
rs249933105012:40,619,059G/T—likely benign
rs55044122012:40,619,062G/A—likely benign
rs7750766212:40,619,063G/C—uncertain significance
rs139447876212:40,619,064T/C—uncertain significance
rs77149179312:40,619,068C/T—likely benign
rs94181123612:40,619,069A/T—uncertain significance
rs78139457512:40,619,070C/T—uncertain significance
rs103618202112:40,619,071G/C—likely benign
rs74629130212:40,619,077C/T—likely benign
rs78123753712:40,619,078G/C—uncertain significance
rs225640812:40,619,082G/G—benign
rs213636454912:40,619,103A/G—likely benign
rs126201363312:40,619,104C/T—likely benign
rs272327312:40,619,301G/A—benign
rs19961008312:40,619,307G/A—benign
rs194082928912:40,619,357C/A—uncertain significance
rs133656395012:40,619,358C/G—likely benign
rs7254633512:40,619,360C/T—not provided
rs20215735412:40,619,363A/G—uncertain significance
rs77664967712:40,619,365T/C—likely benign
rs37048884412:40,619,374G/A—uncertain significance
rs194083160812:40,619,381A/G—uncertain significance
rs15042209912:40,619,382T/A—conflicting classifications of pathogenicity
rs76259311112:40,619,387A/G—uncertain significance
rs249933585912:40,619,388T/A—uncertain significance
rs249933588112:40,619,390T/C—uncertain significance
rs76377912812:40,619,391G/A—likely benign
rs249933592612:40,619,393C/T—uncertain significance
rs249933599212:40,619,397G/C—likely benign
rs75678478312:40,619,398T/C—likely benign
rs194083307412:40,619,403C/G—uncertain significance
rs194083318112:40,619,404G/C—uncertain significance
rs116596034912:40,619,405T/C—uncertain significance
rs213636655812:40,619,406C/T—likely benign
rs155517184212:40,619,414C/T—uncertain significance
rs249933620712:40,619,415C/G—likely benign
rs144204986912:40,619,417A/G—uncertain significance
rs76787272612:40,619,418T/A—uncertain significance
rs194083388812:40,619,419A/G—uncertain significance
rs75094609312:40,619,420T/C—uncertain significance
rs88795435012:40,619,422A/G—uncertain significance
rs249933636412:40,619,423G/T—uncertain significance
rs249933638112:40,619,426T/C—uncertain significance
rs249933640112:40,619,427C/T—likely benign
rs7505413212:40,619,430G/A—likely benign
rs249933646712:40,619,432G/A—uncertain significance
rs194083457912:40,619,433T/C—uncertain significance
rs249933650212:40,619,435T/C—uncertain significance
rs249933651912:40,619,438A/G—uncertain significance
rs249933653012:40,619,439G/A—likely benign
rs20120070712:40,619,462T/A—likely benign
rs225628612:40,619,542A/G—benign
rs149194412:40,619,681A/G—likely benign
rs149194212:40,620,808C/Gregulatory region variant—
rs14821703512:40,625,798T/G—likely benign
rs103034214012:40,626,076G/A—uncertain significance
rs249938101012:40,626,083G/T—uncertain significance
rs249938103512:40,626,086C/T—uncertain significance

Showing 100 of 2,927 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.