LSP1
lymphocyte specific protein 1
Summary
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Known Variants13 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs907611 | 11:1,874,072 | G/A | regulatory region variant | — |
| rs1847403393 | 11:1,874,414 | G/A | — | uncertain significance |
| rs56014530 | 11:1,876,157 | G/A | regulatory region variant | — |
| rs61868760 | 11:1,876,867 | C/G | — | — |
| rs72843943 | 11:1,887,518 | G/A | intron variant | — |
| rs7938342 | 11:1,887,806 | T/G | missense variant | — |
| rs4980388 | 11:1,893,104 | G/T | — | — |
| rs112640876 | 11:1,895,043 | A/G | regulatory region variant | — |
| rs4980386 | 11:1,895,708 | C/A | regulatory region variant | — |
| rs588321 | 11:1,896,957 | G/T | — | — |
| rs61751880 | 11:1,904,736 | G/A | synonymous variant | — |
| rs183535747 | 11:1,905,748 | C/A | — | likely benign |
| rs3817198 | 11:1,909,006 | T/C | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.