MYH7B

myosin heavy chain 7B

Summary

The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]

Known Variants678 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs6088662	20:33,547,633	T/G	upstream gene variant	—
rs11698868	20:33,549,946	C/T	intergenic variant	—
rs6119548	20:33,552,612	A/G	intergenic variant	—
rs6120772	20:33,554,761	C/T	intergenic variant	—
rs73905019	20:33,560,314	C/A	upstream gene variant	—
rs2519083099	20:33,563,316	C/T	—	likely benign
rs1479337101	20:33,565,437	G/T	—	uncertain significance
rs762451146	20:33,565,457	G/T	—	uncertain significance
rs868124121	20:33,565,461	C/T	—	uncertain significance
rs762744206	20:33,565,463	T/A	—	uncertain significance
rs201494323	20:33,565,466	C/T	—	likely benign
rs774018469	20:33,565,472	C/T	—	uncertain significance
rs6060137	20:33,565,480	C/G	—	likely benign
rs2519091463	20:33,565,497	G/A	—	likely benign
rs117616040	20:33,565,528	G/A	—	—
rs757560434	20:33,565,738	G/A	—	uncertain significance
rs11906160	20:33,565,755	G/A	missense variant	benign
rs771694952	20:33,565,794	C/T	—	uncertain significance
rs201230890	20:33,565,817	T/A	—	uncertain significance
rs41312286	20:33,565,873	C/T	—	uncertain significance
rs192594274	20:33,565,874	G/A	—	likely benign
rs766570397	20:33,565,886	T/C	—	likely benign
rs17092199	20:33,565,890	C/A	—	benign
rs2519094416	20:33,565,892	A/C	—	likely benign
rs370258432	20:33,565,895	G/A	—	uncertain significance
rs778824125	20:33,565,898	C/T	—	likely benign
rs6060139	20:33,566,499	T/A	—	—
rs780174991	20:33,567,201	C/T	—	uncertain significance
rs200654846	20:33,567,219	G/A	—	likely benign
rs200981858	20:33,567,222	C/G	—	uncertain significance
rs757047463	20:33,567,228	G/A	—	uncertain significance
rs745470942	20:33,567,233	C/T	—	likely benign
rs779473720	20:33,567,241	C/T	—	uncertain significance
rs368202204	20:33,567,263	C/T	—	likely benign
rs757141332	20:33,567,277	C/T	—	uncertain significance
rs2519099518	20:33,567,285	A/G	—	uncertain significance
rs748812584	20:33,567,297	A/G	—	uncertain significance
rs41309316	20:33,567,299	G/T	—	likely benign
rs375392993	20:33,567,300	G/T	—	uncertain significance
rs201573745	20:33,567,464	G/A	—	likely benign
rs1302348034	20:33,567,469	G/A	—	likely benign
rs749483992	20:33,567,481	A/G	—	likely benign
rs774618536	20:33,567,500	A/G	—	uncertain significance
rs200343489	20:33,567,505	G/A	—	likely benign
rs780505151	20:33,567,531	T/C	—	uncertain significance
rs181482834	20:33,567,575	C/T	—	likely benign
rs766198542	20:33,567,588	A/T	—	uncertain significance
rs373482344	20:33,567,594	G/T	—	uncertain significance
rs780408593	20:33,567,622	C/G	—	likely benign
rs769529263	20:33,568,366	A/G	—	likely benign
rs775154250	20:33,568,375	C/T	—	likely benign
rs560358703	20:33,568,393	C/G	—	uncertain significance
rs202099296	20:33,568,407	C/T	—	benign
rs370219232	20:33,568,447	G/A	—	uncertain significance
rs61746163	20:33,568,455	T/C	—	benign
rs368402495	20:33,568,473	C/T	—	likely benign
rs2519108120	20:33,568,486	C/G	—	uncertain significance
rs1015800857	20:33,568,508	C/T	—	uncertain significance
rs756100723	20:33,568,534	C/T	—	uncertain significance
rs200984501	20:33,568,547	G/T	—	likely benign
rs370367964	20:33,568,838	C/T	—	uncertain significance
rs763409138	20:33,568,847	C/A	—	uncertain significance
rs1428331781	20:33,568,850	T/C	—	uncertain significance
rs761996955	20:33,568,858	G/A	—	likely benign
rs978929874	20:33,568,874	G/A	—	likely benign
rs1384492646	20:33,568,881	G/C	—	likely benign
rs780898297	20:33,570,242	T/G	—	likely benign
rs766570424	20:33,570,270	C/T	—	uncertain significance
rs374055369	20:33,570,277	C/T	—	likely benign
rs201701604	20:33,570,286	G/A	—	likely benign
rs779307780	20:33,570,300	G/A	—	uncertain significance
rs1372056901	20:33,570,318	C/T	—	uncertain significance
rs145840864	20:33,570,322	C/T	—	likely benign
rs773620102	20:33,570,323	G/A	—	uncertain significance
rs767776965	20:33,570,324	T/C	—	uncertain significance
rs776848903	20:33,570,326	G/A	—	uncertain significance
rs553774881	20:33,570,340	C/T	—	likely benign
rs764109123	20:33,570,341	G/A	—	uncertain significance
rs149008892	20:33,570,345	C/T	—	benign
rs750040360	20:33,570,349	C/T	—	uncertain significance
rs779651543	20:33,570,354	A/G	—	uncertain significance
rs2081956457	20:33,570,357	C/T	—	uncertain significance
rs1050997719	20:33,570,359	G/A	—	pathogenic
rs778270256	20:33,572,478	C/T	—	likely benign
rs200297719	20:33,572,514	C/T	—	uncertain significance
rs202107317	20:33,572,515	G/A	—	likely benign
rs201028083	20:33,572,647	A/C	—	benign
rs200324001	20:33,572,649	C/T	—	likely benign
rs188454413	20:33,572,650	G/A	—	benign
rs374653674	20:33,572,670	A/G	—	uncertain significance
rs563043125	20:33,572,688	A/G	—	uncertain significance
rs770823854	20:33,572,709	G/C	—	uncertain significance
rs2147188036	20:33,572,714	G/A	—	uncertain significance
rs547256082	20:33,572,855	C/T	—	benign
rs757267514	20:33,572,882	G/A	—	uncertain significance
rs2081996826	20:33,572,884	A/G	—	uncertain significance
rs372654892	20:33,572,916	C/T	—	likely benign
rs141710855	20:33,572,919	G/A	—	benign
rs2425007	20:33,572,941	A/G	—	benign
rs555025238	20:33,573,886	G/A	—	likely benign

Showing 100 of 678 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.