OTUD7B
OTU deubiquitinase 7B
Summary
Enables K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of protein localization to nucleus; protein deubiquitination; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants54 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1061955 | 1:149,914,357 | G/T | — | — |
| rs1647460269 | 1:149,915,908 | C/T | — | uncertain significance |
| rs370419766 | 1:149,915,910 | C/T | — | uncertain significance |
| rs200128430 | 1:149,915,911 | G/A | — | uncertain significance |
| rs1190639836 | 1:149,915,955 | C/A | — | uncertain significance |
| rs367568103 | 1:149,915,989 | G/T | — | uncertain significance |
| rs368495159 | 1:149,916,127 | C/A | — | uncertain significance |
| rs782031992 | 1:149,916,177 | C/T | — | uncertain significance |
| rs56929499 | 1:149,916,185 | C/A | — | benign |
| rs781876541 | 1:149,916,196 | T/C | — | uncertain significance |
| rs781947466 | 1:149,916,222 | G/C | — | uncertain significance |
| rs1647521505 | 1:149,916,258 | G/A | — | uncertain significance |
| rs782145588 | 1:149,916,400 | G/A | — | uncertain significance |
| rs1553771476 | 1:149,916,414 | T/C | — | uncertain significance |
| rs368587804 | 1:149,916,430 | G/A | — | uncertain significance |
| rs1553771651 | 1:149,916,693 | G/C | — | uncertain significance |
| rs199797117 | 1:149,916,723 | C/T | — | uncertain significance |
| rs2525288031 | 1:149,916,725 | C/G | — | uncertain significance |
| rs1408123431 | 1:149,916,774 | T/G | — | uncertain significance |
| rs782712397 | 1:149,916,803 | G/T | — | likely benign |
| rs781908531 | 1:149,916,813 | C/T | — | uncertain significance |
| rs781900710 | 1:149,916,913 | G/A | — | uncertain significance |
| rs200386540 | 1:149,916,934 | C/T | — | uncertain significance |
| rs376555406 | 1:149,919,190 | T/C | — | uncertain significance |
| rs16838449 | 1:149,920,888 | G/A | — | benign |
| rs782487665 | 1:149,921,574 | C/A | — | uncertain significance |
| rs2525336700 | 1:149,921,630 | G/A | — | uncertain significance |
| rs782062961 | 1:149,922,059 | T/A | — | uncertain significance |
| rs12048493 | 1:149,927,034 | A/C | intron variant | — |
| rs1489260811 | 1:149,931,612 | T/C | — | uncertain significance |
| rs970489063 | 1:149,931,616 | C/T | — | uncertain significance |
| rs1553775275 | 1:149,931,643 | G/T | — | uncertain significance |
| rs184168570 | 1:149,937,800 | C/T | — | uncertain significance |
| rs1649584418 | 1:149,939,243 | T/C | — | uncertain significance |
| rs1370294863 | 1:149,939,245 | G/C | — | uncertain significance |
| rs781882137 | 1:149,939,279 | G/A | — | uncertain significance |
| rs782261183 | 1:149,939,323 | C/T | — | uncertain significance |
| rs199952869 | 1:149,939,383 | T/C | — | uncertain significance |
| rs782327031 | 1:149,939,426 | T/C | — | uncertain significance |
| rs782158140 | 1:149,943,035 | C/T | — | uncertain significance |
| rs1553777540 | 1:149,943,049 | G/C | — | uncertain significance |
| rs115499155 | 1:149,943,088 | C/T | — | benign |
| rs1363736828 | 1:149,943,150 | T/G | — | uncertain significance |
| rs2525563082 | 1:149,949,415 | C/G | — | uncertain significance |
| rs144830380 | 1:149,950,326 | T/C | intron variant | — |
| rs72692842 | 1:149,992,890 | C/T | intergenic variant | — |
| rs72692849 | 1:149,995,966 | C/T | intergenic variant | — |
| rs61584789 | 1:149,997,165 | A/T | — | — |
| rs72692857 | 1:150,001,632 | T/C | intergenic variant | — |
| rs2319280 | 1:150,014,017 | A/T | — | — |
| rs56794080 | 1:150,021,609 | T/C | upstream gene variant | — |
| rs6587748 | 1:150,029,262 | A/C | — | — |
| rs140505938 | 1:150,031,490 | C/T | downstream gene variant | — |
| rs587682044 | 1:150,034,958 | C/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.