PABPC4
poly(A) binding protein cytoplasmic 4
Summary
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021]
Known Variants20 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2522886748 | 1:40,027,392 | G/A | — | uncertain significance |
| rs779538157 | 1:40,027,765 | G/C | — | uncertain significance |
| rs777556247 | 1:40,028,079 | G/C | — | uncertain significance |
| rs4660293 | 1:40,028,180 | A/C | — | — |
| rs1338995379 | 1:40,029,291 | G/C | — | uncertain significance |
| rs766685682 | 1:40,029,329 | G/A | — | uncertain significance |
| rs1421708854 | 1:40,029,378 | C/T | — | uncertain significance |
| rs141523814 | 1:40,029,381 | G/A | — | uncertain significance |
| rs749447901 | 1:40,030,125 | G/A | — | uncertain significance |
| rs760670754 | 1:40,030,141 | A/T | — | likely benign |
| rs564686454 | 1:40,030,167 | T/G | — | uncertain significance |
| rs767586285 | 1:40,031,011 | C/T | — | uncertain significance |
| rs2522927407 | 1:40,034,565 | A/G | — | uncertain significance |
| rs79555286 | 1:40,034,572 | T/C | — | likely benign |
| rs1194823736 | 1:40,035,329 | G/C | — | uncertain significance |
| rs17513135 | 1:40,035,686 | C/A | — | — |
| rs2293476 | 1:40,036,847 | G/C | upstream gene variant | — |
| rs753742336 | 1:40,036,913 | G/A | — | uncertain significance |
| rs16826349 | 1:40,038,936 | G/A | downstream gene variant | — |
| rs12064914 | 1:40,043,772 | G/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.