PREX1
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
Summary
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
Known Variants123 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1380672534 | 20:47,242,431 | C/T | — | uncertain significance |
| rs79164465 | 20:47,244,417 | C/T | — | benign |
| rs140103506 | 20:47,244,418 | G/A | — | uncertain significance |
| rs2515629634 | 20:47,244,426 | C/A | — | uncertain significance |
| rs976517864 | 20:47,246,047 | G/A | — | uncertain significance |
| rs2515633458 | 20:47,246,074 | A/C | — | uncertain significance |
| rs3936192 | 20:47,246,077 | C/G | — | benign |
| rs143436660 | 20:47,246,087 | C/T | — | uncertain significance |
| rs3936193 | 20:47,246,127 | G/A | — | benign |
| rs563839257 | 20:47,247,291 | C/A | — | uncertain significance |
| rs145895841 | 20:47,247,300 | G/A | — | uncertain significance |
| rs1260389720 | 20:47,247,307 | G/C | — | uncertain significance |
| rs769354842 | 20:47,247,316 | G/A | — | uncertain significance |
| rs111654927 | 20:47,248,885 | C/A | — | likely benign |
| rs144664036 | 20:47,249,077 | C/T | — | benign |
| rs4810846 | 20:47,249,591 | T/G | — | — |
| rs201399202 | 20:47,251,303 | C/T | — | uncertain significance |
| rs375868814 | 20:47,253,042 | C/T | — | uncertain significance |
| rs531950971 | 20:47,253,074 | C/A | — | uncertain significance |
| rs149034868 | 20:47,253,124 | G/A | — | likely benign |
| rs145091620 | 20:47,253,168 | C/A | — | uncertain significance |
| rs776805055 | 20:47,253,195 | C/T | — | uncertain significance |
| rs116671299 | 20:47,253,196 | G/A | — | likely benign |
| rs749392176 | 20:47,256,312 | T/G | — | uncertain significance |
| rs143830265 | 20:47,256,372 | T/C | — | likely benign |
| rs2089395205 | 20:47,256,379 | T/C | — | uncertain significance |
| rs2089419016 | 20:47,258,718 | G/A | — | uncertain significance |
| rs746899720 | 20:47,260,956 | T/A | — | uncertain significance |
| rs376069738 | 20:47,262,392 | T/C | — | uncertain significance |
| rs747490930 | 20:47,262,417 | C/T | — | uncertain significance |
| rs6012504 | 20:47,262,549 | C/T | — | benign |
| rs376311381 | 20:47,262,552 | C/G | — | uncertain significance |
| rs1188279149 | 20:47,265,854 | C/T | — | uncertain significance |
| rs2281287 | 20:47,265,918 | G/A | — | benign |
| rs2515672263 | 20:47,265,956 | C/T | — | uncertain significance |
| rs374319615 | 20:47,265,958 | C/G | — | uncertain significance |
| rs186606574 | 20:47,265,959 | G/A | — | uncertain significance |
| rs770586137 | 20:47,265,995 | A/G | — | uncertain significance |
| rs201253741 | 20:47,266,012 | C/A | — | uncertain significance |
| rs758405086 | 20:47,266,086 | C/A | — | uncertain significance |
| rs1389656920 | 20:47,266,096 | G/A | — | uncertain significance |
| rs113202277 | 20:47,266,104 | G/A | — | likely benign |
| rs753748560 | 20:47,266,543 | G/C | — | uncertain significance |
| rs2515675457 | 20:47,267,461 | T/C | — | uncertain significance |
| rs373200161 | 20:47,267,515 | C/T | — | uncertain significance |
| rs532813287 | 20:47,267,545 | T/C | — | likely benign |
| rs747490945 | 20:47,267,593 | T/C | — | uncertain significance |
| rs761435089 | 20:47,267,959 | C/T | — | likely benign |
| rs752025821 | 20:47,267,969 | C/T | — | uncertain significance |
| rs2515676688 | 20:47,267,983 | A/G | — | uncertain significance |
| rs2515676858 | 20:47,268,046 | T/A | — | uncertain significance |
| rs117362968 | 20:47,268,093 | C/G | — | benign |
| rs142986821 | 20:47,268,121 | G/T | — | uncertain significance |
| rs1601046619 | 20:47,269,204 | T/G | — | uncertain significance |
| rs200304859 | 20:47,269,225 | T/C | — | uncertain significance |
| rs139921407 | 20:47,269,919 | T/C | — | uncertain significance |
| rs146210678 | 20:47,269,963 | T/C | — | likely benign |
| rs371255905 | 20:47,269,970 | C/T | — | uncertain significance |
| rs373710294 | 20:47,269,981 | T/C | — | uncertain significance |
| rs193131466 | 20:47,271,858 | C/T | — | uncertain significance |
| rs112806196 | 20:47,271,866 | C/T | — | likely benign |
| rs377520743 | 20:47,271,867 | G/A | — | uncertain significance |
| rs144910943 | 20:47,271,868 | A/C | — | uncertain significance |
| rs780422601 | 20:47,271,907 | G/C | — | uncertain significance |
| rs373231511 | 20:47,273,606 | G/A | — | uncertain significance |
| rs2515686687 | 20:47,273,659 | A/C | — | uncertain significance |
| rs146847114 | 20:47,274,697 | C/T | — | uncertain significance |
| rs150394441 | 20:47,276,464 | C/T | — | uncertain significance |
| rs2089578226 | 20:47,276,518 | T/C | — | uncertain significance |
| rs753153560 | 20:47,276,587 | C/A | — | uncertain significance |
| rs1218854501 | 20:47,282,838 | T/C | — | uncertain significance |
| rs146526094 | 20:47,282,861 | C/T | — | benign |
| rs11086258 | 20:47,292,329 | T/G | — | — |
| rs141743214 | 20:47,292,761 | C/T | — | likely benign |
| rs368786438 | 20:47,295,943 | A/G | — | uncertain significance |
| rs199844877 | 20:47,296,196 | A/G | — | uncertain significance |
| rs776554572 | 20:47,305,300 | G/A | — | uncertain significance |
| rs769704154 | 20:47,305,307 | T/C | — | uncertain significance |
| rs1487851710 | 20:47,307,502 | T/A | — | uncertain significance |
| rs139463608 | 20:47,307,600 | G/A | — | likely benign |
| rs6095241 | 20:47,308,798 | G/A | intron variant | — |
| rs6019378 | 20:47,309,716 | C/T | intron variant | — |
| rs2515754607 | 20:47,317,406 | T/G | — | uncertain significance |
| rs960129149 | 20:47,317,407 | G/T | — | uncertain significance |
| rs4810864 | 20:47,319,142 | G/C | regulatory region variant | — |
| rs2869669 | 20:47,321,449 | T/C | intron variant | — |
| rs772697635 | 20:47,324,949 | T/C | — | uncertain significance |
| rs6019386 | 20:47,326,440 | T/G | intron variant | — |
| rs6066825 | 20:47,340,117 | A/G | regulatory region variant | — |
| rs6063312 | 20:47,343,059 | G/T | intron variant | — |
| rs777743255 | 20:47,351,146 | A/C | — | uncertain significance |
| rs6066835 | 20:47,355,009 | T/C | regulatory region variant | — |
| rs145026241 | 20:47,361,630 | C/A | — | likely benign |
| rs2090101649 | 20:47,361,635 | A/G | — | uncertain significance |
| rs560564311 | 20:47,375,302 | T/C | — | — |
| rs2426087 | 20:47,379,811 | G/A | regulatory region variant | — |
| rs149257976 | 20:47,384,301 | C/A | intron variant | — |
| rs6125462 | 20:47,388,649 | C/G | — | — |
| rs75240985 | 20:47,391,484 | G/A | intron variant | — |
| rs6090907 | 20:47,410,231 | G/A | intron variant | — |
Showing 100 of 123 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.