SHLD2
shieldin complex subunit 2
Summary
Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in actin cytoskeleton; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants63 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs145319623 | 10:88,861,211 | T/C | intron variant | — |
| rs138080325 | 10:88,869,475 | A/G | upstream gene variant | — |
| rs3129469 | 10:88,895,315 | T/A | — | — |
| rs3129353 | 10:88,901,802 | T/A | — | — |
| rs11202345 | 10:88,908,801 | T/C | regulatory region variant | — |
| rs11202346 | 10:88,908,912 | G/T | regulatory region variant | — |
| rs1472012080 | 10:88,911,122 | G/A | — | uncertain significance |
| rs779061912 | 10:88,911,388 | G/T | — | uncertain significance |
| rs137989844 | 10:88,911,464 | C/G | — | uncertain significance |
| rs192846566 | 10:88,911,494 | C/T | — | uncertain significance |
| rs1468245485 | 10:88,911,499 | C/T | — | uncertain significance |
| rs534044465 | 10:88,911,587 | G/A | — | uncertain significance |
| rs2540396129 | 10:88,911,589 | G/C | — | uncertain significance |
| rs150604440 | 10:88,911,772 | A/G | — | likely benign |
| rs2540397826 | 10:88,911,784 | G/A | — | uncertain significance |
| rs140118356 | 10:88,911,874 | G/A | — | uncertain significance |
| rs772158677 | 10:88,911,919 | G/A | — | likely benign |
| rs150029582 | 10:88,911,925 | A/G | — | benign |
| rs763971624 | 10:88,911,946 | A/G | — | uncertain significance |
| rs753768939 | 10:88,911,947 | G/A | — | uncertain significance |
| rs374271968 | 10:88,911,949 | T/G | — | uncertain significance |
| rs565758997 | 10:88,911,952 | G/A | — | uncertain significance |
| rs377718754 | 10:88,911,959 | T/C | — | uncertain significance |
| rs776562213 | 10:88,912,016 | G/A | — | uncertain significance |
| rs1846077421 | 10:88,912,094 | A/G | — | uncertain significance |
| rs1172776304 | 10:88,912,168 | G/A | — | uncertain significance |
| rs201907610 | 10:88,912,169 | A/G | — | uncertain significance |
| rs1846083479 | 10:88,912,198 | A/G | — | uncertain significance |
| rs757655813 | 10:88,912,222 | T/C | — | uncertain significance |
| rs768978856 | 10:88,912,300 | C/G | — | uncertain significance |
| rs777034269 | 10:88,912,303 | G/C | — | uncertain significance |
| rs1235430227 | 10:88,912,328 | C/G | — | uncertain significance |
| rs747913567 | 10:88,912,331 | A/G | — | uncertain significance |
| rs142798867 | 10:88,912,360 | C/T | — | uncertain significance |
| rs572583042 | 10:88,912,427 | G/T | — | uncertain significance |
| rs759004181 | 10:88,912,634 | C/T | — | uncertain significance |
| rs3129500 | 10:88,915,107 | A/T | — | — |
| rs148634820 | 10:88,917,806 | T/A | — | uncertain significance |
| rs768200675 | 10:88,917,856 | C/T | — | uncertain significance |
| rs142064377 | 10:88,917,876 | A/G | — | uncertain significance |
| rs7903456 | 10:88,919,319 | C/T | intron variant | — |
| rs60783257 | 10:88,922,632 | T/A | — | — |
| rs4934310 | 10:88,929,623 | G/A | — | — |
| rs4934311 | 10:88,929,652 | C/A | — | — |
| rs11202365 | 10:88,930,249 | A/T | missense variant | — |
| rs146511329 | 10:88,930,261 | C/T | — | uncertain significance |
| rs751441138 | 10:88,930,319 | C/T | — | uncertain significance |
| rs375357078 | 10:88,930,388 | T/C | — | uncertain significance |
| rs1410523230 | 10:88,930,424 | T/C | — | uncertain significance |
| rs542979117 | 10:88,939,849 | G/A | — | uncertain significance |
| rs762408418 | 10:88,939,889 | A/G | — | uncertain significance |
| rs754271785 | 10:88,939,913 | G/A | — | uncertain significance |
| rs779340471 | 10:88,939,921 | A/G | — | uncertain significance |
| rs7081609 | 10:88,939,962 | T/A | synonymous variant | — |
| rs3129430 | 10:88,942,570 | G/A | intron variant | — |
| rs4515883 | 10:88,943,267 | T/C | intron variant | — |
| rs370213577 | 10:88,946,888 | C/T | — | uncertain significance |
| rs6586063 | 10:88,949,045 | A/G | intron variant | — |
| rs1432635239 | 10:88,950,288 | C/T | — | uncertain significance |
| rs200904581 | 10:88,950,292 | C/G | — | uncertain significance |
| rs373996048 | 10:88,950,309 | G/A | — | uncertain significance |
| rs200709640 | 10:88,950,418 | A/T | — | uncertain significance |
| rs3129399 | 10:88,951,662 | A/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.