SLC22A2
solute carrier family 22 member 2
Pharmacogene
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
Known Variants49 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs8177518 | 6:160,242,437 | A/G | intron variant | — |
| rs8177510 | 6:160,250,552 | G/A | synonymous variant | — |
| rs8177509 | 6:160,256,651 | A/G | missense variant | — |
| rs139737555 | 6:160,645,763 | T/G | — | benign |
| rs144511904 | 6:160,645,766 | C/G | — | uncertain significance |
| rs316006 | 6:160,646,365 | T/C | — | — |
| rs138968449 | 6:160,650,291 | C/T | intron variant | — |
| rs11753349 | 6:160,652,678 | A/G | intron variant | — |
| rs184091076 | 6:160,654,815 | G/A | intron variant | — |
| rs138281088 | 6:160,656,533 | C/A | — | — |
| rs3907238 | 6:160,658,422 | G/A | — | — |
| rs315986 | 6:160,659,952 | C/A | — | — |
| rs113187109 | 6:160,660,943 | T/A | intron variant | — |
| rs3101823 | 6:160,661,168 | T/G | — | — |
| rs2483095130 | 6:160,662,592 | G/A | — | uncertain significance |
| rs530352058 | 6:160,662,617 | T/C | — | uncertain significance |
| rs3127606 | 6:160,662,910 | T/C | — | — |
| rs8177517 | 6:160,663,420 | T/G | missense variant | — |
| rs1452622174 | 6:160,664,607 | C/T | — | uncertain significance |
| rs8177515 | 6:160,664,680 | G/A | — | likely benign |
| rs8177516 | 6:160,664,685 | G/T | missense variant | — |
| rs371567930 | 6:160,664,689 | G/A | — | likely benign |
| rs1298095792 | 6:160,664,739 | A/C | — | uncertain significance |
| rs756083599 | 6:160,664,765 | C/T | — | uncertain significance |
| rs201472618 | 6:160,664,778 | T/C | — | uncertain significance |
| rs766844924 | 6:160,666,576 | C/T | — | uncertain significance |
| rs758136736 | 6:160,666,577 | G/A | — | uncertain significance |
| rs316022 | 6:160,667,600 | G/C | — | — |
| rs2279463 | 6:160,668,389 | A/T | — | — |
| rs316020 | 6:160,669,081 | A/T | — | — |
| rs756584538 | 6:160,670,272 | T/A | — | uncertain significance |
| rs316019 | 6:160,670,282 | A/T | missense variant | — |
| rs762880984 | 6:160,670,318 | C/T | — | uncertain significance |
| rs750500162 | 6:160,670,350 | A/G | — | uncertain significance |
| rs371586429 | 6:160,670,399 | G/A | — | uncertain significance |
| rs947982374 | 6:160,670,410 | T/G | — | uncertain significance |
| rs201919874 | 6:160,671,657 | G/A | missense variant | — |
| rs376744152 | 6:160,671,673 | T/C | — | uncertain significance |
| rs316014 | 6:160,672,506 | A/T | intron variant | — |
| rs3127579 | 6:160,674,632 | G/A | intron variant | — |
| rs369855766 | 6:160,677,692 | C/T | — | uncertain significance |
| rs931651372 | 6:160,677,730 | T/C | — | uncertain significance |
| rs773971925 | 6:160,679,417 | C/T | — | uncertain significance |
| rs773192589 | 6:160,679,428 | G/C | — | uncertain significance |
| rs755217303 | 6:160,679,519 | G/A | — | uncertain significance |
| rs532711865 | 6:160,679,545 | C/T | — | uncertain significance |
| rs775454899 | 6:160,679,575 | T/G | — | uncertain significance |
| rs1017655480 | 6:160,679,605 | C/T | — | uncertain significance |
| rs3127573 | 6:160,681,393 | A/G | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.