SOS2

SOS Ras/Rho guanine nucleotide exchange factor 2

Summary

This gene encodes a regulatory protein that is involved in the positive regulation of ras proteins. Mutations in this gene are associated with Noonan Syndrome-9. [provided by RefSeq, Jul 2016]

Known Variants1,285 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2139461520	14:50,584,828	C/T	—	uncertain significance
rs74714090	14:50,585,012	A/T	—	likely benign
rs142666803	14:50,585,064	A/G	—	uncertain significance
rs938858514	14:50,585,065	T/C	—	likely benign
rs146527239	14:50,585,074	T/G	—	conflicting classifications of pathogenicity
rs776266602	14:50,585,077	T/C	—	likely benign
rs527576404	14:50,585,080	A/G	—	likely benign
rs764819181	14:50,585,086	T/C	—	likely benign
rs886041929	14:50,585,093	G/A	—	uncertain significance
rs2502753477	14:50,585,096	A/G	—	uncertain significance
rs766057658	14:50,585,101	G/A	—	likely benign
rs950322034	14:50,585,103	A/G	—	uncertain significance
rs2139462748	14:50,585,104	C/A	—	uncertain significance
rs751408063	14:50,585,107	T/C	—	likely benign
rs1433339408	14:50,585,108	G/T	—	uncertain significance
rs140995728	14:50,585,109	G/T	—	uncertain significance
rs749513697	14:50,585,110	G/C	—	likely benign
rs143427064	14:50,585,116	C/T	—	likely benign
rs865922330	14:50,585,117	G/A	—	conflicting classifications of pathogenicity
rs746317294	14:50,585,122	C/G	—	conflicting classifications of pathogenicity
rs772673873	14:50,585,126	C/T	—	conflicting classifications of pathogenicity
rs775973831	14:50,585,127	G/T	—	likely benign
rs1214781595	14:50,585,131	G/C	—	uncertain significance
rs2502754071	14:50,585,133	A/G	—	uncertain significance
rs759124324	14:50,585,159	T/C	—	conflicting classifications of pathogenicity
rs184739336	14:50,585,160	G/A	—	conflicting classifications of pathogenicity
rs1340925625	14:50,585,163	G/A	—	uncertain significance
rs2502754411	14:50,585,178	T/G	—	likely benign
rs1244881868	14:50,585,192	G/T	—	uncertain significance
rs761580972	14:50,585,193	G/C	—	conflicting classifications of pathogenicity
rs900986254	14:50,585,199	G/A	—	uncertain significance
rs2502754683	14:50,585,200	A/G	—	likely benign
rs1883381723	14:50,585,211	G/C	—	uncertain significance
rs1417984521	14:50,585,212	A/G	—	likely benign
rs376158218	14:50,585,216	T/C	—	uncertain significance
rs2502755027	14:50,585,219	T/C	—	uncertain significance
rs2502755092	14:50,585,223	T/G	—	uncertain significance
rs1165501637	14:50,585,224	A/G	—	likely benign
rs2502755162	14:50,585,229	T/C	—	uncertain significance
rs146802994	14:50,585,231	A/G	—	likely benign
rs1163199209	14:50,585,236	A/G	—	likely benign
rs371619971	14:50,585,237	T/C	—	likely benign
rs58365465	14:50,585,243	C/T	—	conflicting classifications of pathogenicity
rs2502755424	14:50,585,244	G/A	—	uncertain significance
rs200104745	14:50,585,246	C/T	—	conflicting classifications of pathogenicity
rs1005498417	14:50,585,247	G/T	—	uncertain significance
rs2227276	14:50,585,248	C/G	—	likely benign
rs1286260102	14:50,585,249	G/A	—	conflicting classifications of pathogenicity
rs2502755636	14:50,585,251	T/C	—	likely benign
rs757528344	14:50,585,253	C/T	—	uncertain significance
rs2502755779	14:50,585,256	T/C	—	uncertain significance
rs2502755834	14:50,585,261	G/A	—	uncertain significance
rs1271341173	14:50,585,263	G/C	—	likely benign
rs2139464021	14:50,585,264	G/A	—	uncertain significance
rs2139464050	14:50,585,267	G/A	—	uncertain significance
rs1053118797	14:50,585,268	T/C	—	likely benign
rs569343105	14:50,585,273	G/C	—	conflicting classifications of pathogenicity
rs2139464111	14:50,585,276	G/A	—	uncertain significance
rs2502756149	14:50,585,277	G/A	—	uncertain significance
rs780772018	14:50,585,279	G/C	—	conflicting classifications of pathogenicity
rs1555367637	14:50,585,280	T/G	—	uncertain significance
rs1163048019	14:50,585,282	C/T	—	likely benign
rs747521589	14:50,585,287	C/T	—	likely benign
rs769093505	14:50,585,288	G/A	—	conflicting classifications of pathogenicity
rs1344396759	14:50,585,289	A/C	—	conflicting classifications of pathogenicity
rs150393358	14:50,585,292	T/C	—	likely benign
rs747726856	14:50,585,294	G/T	—	uncertain significance
rs769536087	14:50,585,299	C/T	—	likely benign
rs772587016	14:50,585,300	G/C	—	uncertain significance
rs762593451	14:50,585,303	C/G	—	conflicting classifications of pathogenicity
rs2502756645	14:50,585,305	A/C	—	uncertain significance
rs1221719767	14:50,585,314	G/A	—	likely benign
rs138133010	14:50,585,317	C/A	—	likely benign
rs1883393016	14:50,585,320	G/C	—	uncertain significance
rs767257405	14:50,585,323	T/G	—	likely benign
rs752525400	14:50,585,326	A/C	—	conflicting classifications of pathogenicity
rs761917783	14:50,585,332	G/A	—	likely benign
rs1471245340	14:50,585,339	T/C	—	conflicting classifications of pathogenicity
rs2502757053	14:50,585,340	G/A	—	uncertain significance
rs2502757083	14:50,585,342	C/G	—	uncertain significance
rs1406914864	14:50,585,347	T/A	—	likely benign
rs2502757245	14:50,585,353	T/C	—	likely benign
rs1403796339	14:50,585,354	G/A	—	uncertain significance
rs2502757277	14:50,585,355	G/A	—	uncertain significance
rs2502757335	14:50,585,361	G/C	—	uncertain significance
rs201756168	14:50,585,363	T/G	—	conflicting classifications of pathogenicity
rs2502757575	14:50,585,377	T/A	—	likely benign
rs781674653	14:50,585,379	T/C	—	likely benign
rs748607274	14:50,585,380	A/T	—	uncertain significance
rs2502757633	14:50,585,382	A/C	—	uncertain significance
rs2502757647	14:50,585,383	G/C	—	uncertain significance
rs1018592964	14:50,585,384	T/C	—	uncertain significance
rs769329817	14:50,585,388	C/G	—	conflicting classifications of pathogenicity
rs149321983	14:50,585,389	T/G	—	likely benign
rs1883396353	14:50,585,390	G/A	—	uncertain significance
rs1202582363	14:50,585,396	C/T	—	conflicting classifications of pathogenicity
rs1232489201	14:50,585,397	G/A	—	conflicting classifications of pathogenicity
rs2502757823	14:50,585,398	A/C	—	likely benign
rs2502757911	14:50,585,404	A/C	—	likely benign
rs2502757920	14:50,585,406	C/T	—	uncertain significance

Showing 100 of 1,285 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.