TMEM163
transmembrane protein 163
Summary
Predicted to enable zinc ion binding activity. Involved in myelination and zinc export across plasma membrane. Predicted to be located in early endosome membrane. Predicted to be active in plasma membrane and synaptic vesicle membrane. Implicated in hypomyelinating leukodystrophy 25. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants36 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1364059830 | 2:135,214,321 | A/G | — | uncertain significance |
| rs1199922536 | 2:135,214,322 | C/T | — | uncertain significance |
| rs756653755 | 2:135,214,327 | G/A | — | uncertain significance |
| rs10179686 | 2:135,214,570 | C/T | downstream gene variant | — |
| rs2468392381 | 2:135,215,618 | A/T | — | uncertain significance |
| rs1686441400 | 2:135,215,628 | G/C | — | uncertain significance |
| rs765196021 | 2:135,215,660 | T/C | — | uncertain significance |
| rs145809313 | 2:135,215,721 | C/T | — | uncertain significance |
| rs201768833 | 2:135,223,739 | C/T | — | uncertain significance |
| rs767849159 | 2:135,260,549 | C/T | — | uncertain significance |
| rs2468450947 | 2:135,260,564 | A/C | — | uncertain significance |
| rs56131490 | 2:135,263,081 | G/A | intron variant | — |
| rs487404 | 2:135,300,861 | A/T | — | — |
| rs148040253 | 2:135,308,153 | T/C | — | uncertain significance |
| rs2468508848 | 2:135,308,162 | T/C | — | pathogenic |
| rs2468508850 | 2:135,308,165 | A/T | — | uncertain significance |
| rs2468508886 | 2:135,308,187 | G/A | — | pathogenic |
| rs842349 | 2:135,342,452 | G/T | intron variant | — |
| rs842357 | 2:135,345,059 | G/A | intron variant | — |
| rs1818613 | 2:135,356,285 | G/A | — | — |
| rs187381978 | 2:135,377,597 | C/G | intron variant | — |
| rs17789633 | 2:135,386,474 | A/C | intron variant | — |
| rs6739706 | 2:135,407,409 | A/C | intron variant | — |
| rs62171367 | 2:135,408,637 | G/A | — | — |
| rs7560738 | 2:135,419,163 | A/G | intron variant | — |
| rs998451 | 2:135,429,288 | G/A | regulatory region variant | — |
| rs4954162 | 2:135,438,789 | G/A | intron variant | — |
| rs2467325671 | 2:135,470,865 | A/G | — | pathogenic |
| rs753163132 | 2:135,476,315 | A/C | — | uncertain significance |
| rs1336736091 | 2:135,476,348 | C/T | — | uncertain significance |
| rs1685097140 | 2:135,476,353 | C/G | — | uncertain significance |
| rs1291025065 | 2:135,476,366 | T/A | — | uncertain significance |
| rs946626560 | 2:135,476,396 | C/T | — | uncertain significance |
| rs1252903387 | 2:135,476,406 | C/G | — | uncertain significance |
| rs1056588159 | 2:135,476,420 | G/A | — | uncertain significance |
| rs887919585 | 2:135,476,466 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.