TNFSF13B
TNF superfamily member 13b
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Known Variants15 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9514828 | 13:108,921,373 | C/T | regulatory region variant | — |
| rs2501759492 | 13:108,922,386 | T/A | — | uncertain significance |
| rs2501759554 | 13:108,922,395 | C/G | — | uncertain significance |
| rs1303186225 | 13:108,922,448 | G/A | — | uncertain significance |
| rs201543678 | 13:108,922,556 | G/A | — | benign |
| rs1224141 | 13:108,935,723 | T/G | intron variant | — |
| rs1224142 | 13:108,936,715 | C/T | — | — |
| rs12583006 | 13:108,937,452 | T/A | intron variant | — |
| rs2501795706 | 13:108,939,198 | A/G | — | uncertain significance |
| rs10508198 | 13:108,942,788 | G/T | — | — |
| rs1224145 | 13:108,955,464 | C/G | — | benign |
| rs1594535542 | 13:108,955,614 | T/C | — | likely benign |
| rs77273581 | 13:108,955,933 | T/C | — | benign |
| rs1224146 | 13:108,956,169 | T/A | — | benign |
| rs374039502 | 13:108,960,385 | T/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.