VMP1
vacuole membrane protein 1
Summary
This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7224195 | 17:57,801,488 | A/G | intron variant | — |
| rs72840511 | 17:57,806,011 | G/T | intron variant | — |
| rs201900647 | 17:57,812,787 | G/T | — | uncertain significance |
| rs4968393 | 17:57,813,824 | A/G | intron variant | — |
| rs11654074 | 17:57,825,572 | A/C | intron variant | — |
| rs2777885 | 17:57,830,473 | C/T | — | — |
| rs57240614 | 17:57,832,501 | C/T | — | — |
| rs2509365077 | 17:57,842,402 | A/G | — | uncertain significance |
| rs201472232 | 17:57,842,446 | A/G | — | likely benign |
| rs11650106 | 17:57,850,251 | C/T | regulatory region variant | — |
| rs56251713 | 17:57,861,501 | T/G | — | — |
| rs2665391 | 17:57,861,503 | T/G | — | — |
| rs2645474 | 17:57,868,601 | G/A | intron variant | — |
| rs34079854 | 17:57,870,246 | T/A | — | — |
| rs2777900 | 17:57,872,494 | G/C | — | — |
| rs2777895 | 17:57,879,610 | A/G | intron variant | — |
| rs12449331 | 17:57,883,646 | T/A | — | — |
| rs11079389 | 17:57,887,952 | G/A | regulatory region variant | — |
| rs201958788 | 17:57,889,065 | C/T | — | uncertain significance |
| rs2173120 | 17:57,892,640 | A/T | intron variant | — |
| rs115869798 | 17:57,892,829 | T/A | — | — |
| rs4257266 | 17:57,894,459 | A/G | intron variant | — |
| rs143341655 | 17:57,895,725 | C/G | intron variant | — |
| rs11079390 | 17:57,895,941 | C/A | — | — |
| rs2333617 | 17:57,896,220 | T/A | intron variant | — |
| rs12938273 | 17:57,901,652 | G/A | intron variant | — |
| rs2526352 | 17:57,904,823 | A/T | — | — |
| rs1292063 | 17:57,907,768 | T/G | — | — |
| rs62081824 | 17:57,907,950 | A/G | regulatory region variant | — |
| rs1295925 | 17:57,910,263 | T/C | regulatory region variant | — |
| rs2509533847 | 17:57,915,747 | G/T | — | uncertain significance |
| rs1461157069 | 17:57,917,145 | C/T | — | uncertain significance |
| rs749338275 | 17:57,917,168 | G/A | — | uncertain significance |
| rs866544435 | 17:57,917,192 | C/G | — | uncertain significance |
| rs2509537184 | 17:57,917,198 | A/C | — | uncertain significance |
| rs182811044 | 17:57,917,621 | T/C | regulatory region variant | — |
| rs1292037 | 17:57,918,908 | T/C | regulatory region variant | — |
| rs13137 | 17:57,919,031 | A/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.