rs10433937
This is a intron variant variant in the HSD17B13 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Abnormality of the liver
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.17
p 2.0e-69
N 428,257
Major Consortium StudyLarge GWAS
European
platelet count
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 1.0e-47
N 406,601
Major Consortium StudyLarge GWAS
European
alcoholic liver cirrhosis
Schwantes-An TH et al. “Genome-wide Association Study and Meta-analysis on Alcohol-Associated Liver Cirrhosis Identifies Genetic Risk Factors.” Hepatology (baltimore, Md.) 73(5):1920-1931 (2021)
Allele T
OR 0.26
p 3.0e-10
N 1,977
Meta-analysis
European
aspartate aminotransferase to alanine aminotransferase ratio
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.04
p 4.0e-42
N 562,117
Major Consortium StudyLarge GWAS
multi-ancestry
serum alanine aminotransferase amount
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.04
p 4.0e-53
N 584,062
Major Consortium StudyLarge GWAS
multi-ancestry
Vujkovic M et al. “A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.” Nature Genetics 54(6):761-771 (2022)
Allele T
OR 0.08
p 5.0e-26
N 218,595
Large GWAS
multi-ancestry
About HSD17B13
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Acts upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]
View all HSD17B13 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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