rs10876864

This variant is located in the IKZF4 gene.

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GWAS Catalog Trait Associations (14)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

basal cell carcinoma

Seviiri M et al. “A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma.” Nature Communications 13(1):7650 (2022)
Allele A
OR —
p 2.0e-21
N 307,684
Large GWAS
European

allergic disease

Ferreira MA et al. “Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.” Nature Genetics 49(12):1752-1757 (2017)
Allele G
OR 1.05
p 1.0e-19
N 360,838
Large GWAS
European

eosinophil count

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.01
p 2.0e-18
N 442,919
Large GWAS
multi-ancestry

glypican-1 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.04
p 4.0e-18
N 47,745
Large GWAS
European

squamous cell carcinoma

Seviiri M et al. “A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma.” Nature Communications 13(1):7650 (2022)
Allele A
OR —
p 2.0e-15
N 294,294
Large GWAS
European

eosinophil percentage of leukocytes

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele A
OR 0.03
p 4.0e-14
N 172,378
Large GWAS
European

household income

Hill WD et al. “Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income.” Nature Communications 10(1):5741 (2019)
Allele A
OR 0.02
p 8.0e-14
N 505,541
Large GWAS
European, NR

intelligence

Hill WD et al. “A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.” Molecular Psychiatry 24(2):169-181 (2019)
Allele A
OR 0.02
p 2.0e-12
N 248,482
Large GWAS
European

Vitiligo

Tang XF et al. “Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.” The Journal of Investigative Dermatology 133(2):403-10 (2013)
Allele G
OR 1.18
p 8.0e-12
N 2,818
Large GWAS
East Asian

eosinophil percentage of granulocytes

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele A
OR 0.02
p 1.0e-11
N 170,536
Large GWAS
European
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Research that mentions this SNP (1)

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Polymorphisms in chromosome region 12q13 and their influence on age at onset of type 1 diabetes
AssociationN=1,305Espino-Paisan L. et al.(2011)· Diabetologia

This case-control study examined three SNPs (rs773107, rs2292239, rs10876864) in chromosome region 12q13 for associations with type 1 diabetes age at onset in 444 Spanish diabetic patients and 861 controls. rs773107 and rs2292239 showed significant associations with disease (p ≤0.008 and p=0.03, respectively), with early-onset patients (≤16 years) showing stronger associations than late-onset patients. Subjects with risk genotypes had disease onset 2-5 years earlier than protective allele carriers.

Traits studied:Age at onset of type 1 diabetesType 1 diabetes
PubMedDOIMetascience Observatory

About IKZF4

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

View all IKZF4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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