rs115378818

This is a intron variant variant in the TSBP1 gene.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

inflammatory bowel disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.88

p 5.0e-67

N 626,677

Major Consortium StudyLarge GWAS

multi-ancestry

Beecham AH et al. “Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.” Gastroenterology (2026)

Allele C

OR 4.24

p 4.0e-18

N 6,669

Large GWAS

Hispanic or Latin American

lymphocyte count

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele T

OR 0.17

p 3.0e-49

N 408,112

Large GWAS

European

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.14

p 2.0e-28

N 417,277

Major Consortium StudyLarge GWAS

multi-ancestry

neutrophil count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.18

p 4.0e-31

N 369,386

Major Consortium StudyLarge GWAS

multi-ancestry

Crohn's disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.79

p 4.0e-15

N 371,173

Major Consortium StudyLarge GWAS

multi-ancestry

Beecham AH et al. “Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.” Gastroenterology (2026)

Allele C

OR 3.53

p 2.0e-9

N 5,962

Large GWAS

Hispanic or Latin American

enteritis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.91

p 6.0e-27

N 450,033

Major Consortium StudyLarge GWAS

European

ileostomy

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 1.07

p 2.0e-22

N 450,813

Major Consortium StudyLarge GWAS

European

ulcerative colitis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.81

p 2.0e-29

N 400,487

Major Consortium StudyLarge GWAS

multi-ancestry

Beecham AH et al. “Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.” Gastroenterology (2026)

Allele C

OR 4.68

p 5.0e-15

N 5,714

Large GWAS

Hispanic or Latin American

About TSBP1

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all TSBP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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