rs11581607
This is a upstream gene variant variant in the IL23R gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
inflammatory bowel disease
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.40
p 3.0e-26
N 626,677
Major Consortium StudyLarge GWAS
multi-ancestry
Wu Y et al. “GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression.” Nature Communications 12(1):1146 (2021)
Allele G
OR 1.51
p 2.0e-24
N 456,327
Large GWAS
European
psoriasis
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.24
p 8.0e-23
N 443,794
Major Consortium StudyLarge GWAS
European
psoriasis vulgaris
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.24
p 8.0e-22
N 444,887
Major Consortium StudyLarge GWAS
European
interleukin-23 receptor measurement
Allele A
OR —
β 0.420
p 1.0e-17
N 3,301
Large GWAS
European
ulcerative colitis
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.37
p 2.0e-12
N 315,668
Major Consortium StudyLarge GWAS
European
Zeng Y et al. “Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.” The American Journal of Psychiatry 180(4):294-304 (2023)
Allele G
OR 0.70
p 7.0e-11
N 376,871
Large GWAS
European
About IL23R
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
View all IL23R variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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