rs11682175

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele T
OR 0.02
p 3.0e-14
N 1,349,887
Large GWAS
European
Wray NR et al. “Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.” Nature Genetics 50(5):668-681 (2018)
Allele T
OR 1.03
p 5.0e-9
N 480,359
Large GWAS
European

sleep duration trait

Jansen PR et al. “Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.” Nature Genetics 51(3):394-403 (2019)
Allele C
OR 0.02
p 1.0e-13
N 384,317
Large GWAS
European

alcohol consumption quality

Kember RL et al. “Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.” The American Journal of Psychiatry 180(8):584-593 (2023)
Allele T
OR 7.28
p 3.0e-13
N 409,630
Large GWAS
multi-ancestry

schizophrenia

Goes FS et al. “Genome-wide association study of schizophrenia in Ashkenazi Jews.” American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics 168(8):649-59 (2015)
Allele C
OR 1.08
p 1.0e-12
N 151,161
Large GWAS
Other
Ikeda M et al. “Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.” Schizophrenia Bulletin 45(4):824-834 (2019)
Allele C
OR 1.08
p 2.0e-11
N 122,624
Large GWAS
multi-ancestry
“Biological insights from 108 schizophrenia-associated genetic loci.” Nature 511(7510):421-7 (2014)
Allele C
OR 1.07
p 1.0e-11
N 83,550
Large GWAS
multi-ancestry
Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)
Allele C
OR 0.08
p 4.0e-12
N 77,096
Large GWAS
European

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele T
OR 6.71
p 2.0e-11
N 1,699,295
Large GWAS
multi-ancestry

irritability measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele T
OR 5.70
p 1.0e-8
N 366,726
Large GWAS
European
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Research that mentions this SNP (1)

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Common variants in QPCT gene confer risk of schizophrenia in the Han Chinese population
MethodsRaja Amjad Waheed Khan et al.(2016)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This paper presents CalPen, a web-based tool for calculating penetrance (disease likelihood given a mutation) in complex genetic disorders. The authors validated CalPen against published penetrance calculations for schizophrenia-associated copy number variants (CNVs) and single nucleotide polymorphisms (SNPs). They analyzed 15 CNVs in 39,059 schizophrenia patients and 55,084 controls (average penetrance 7%, ranging from ~1.4% for 15q11.2 deletions to ~20% for 22q11.21 CNVs) and 145 SNPs in 45,405 patients and 122,761 controls (average penetrance 0.7%, with rs1801028 showing the highest at 1.6%).

Traits studied:Schizophrenia
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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