rs12231737
This is a intron variant variant in the TRAFD1 gene.
▶GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
high density lipoprotein cholesterol measurement
Lee SB et al. “Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease.” Biomedicines 10(7) (2022)
Allele T
OR 1.35
p 7.0e-43
N 58,701
Large GWAS
East Asian
energy intake
Suzuki T et al. “A genome-wide association study on confection consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort Study.” The British Journal of Nutrition 126(12):1843-1851 (2021)
Allele T
OR 1.70
p 3.0e-29
N 14,073
Large GWAS
East Asian
glomerular filtration rate
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele T
OR 0.81
p 6.0e-19
N 58,406
Large GWAS
East Asian
blood urea nitrogen amount
Lee DJ et al. “Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.” Kidney Research and Clinical Practice 43(3):299-312 (2024)
Allele T
OR 0.02
p 5.0e-18
N 58,406
Large GWAS
East Asian
carbohydrate intake measurement
Nakamura Y et al. “A genome-wide association study on adherence to low-carbohydrate diets in Japanese.” European Journal of Clinical Nutrition 76(8):1103-1110 (2022)
Allele T
OR —
p 2.0e-15
N 14,076
Large GWAS
East Asian
cups of coffee per day measurement
Choe EK et al. “Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.” Scientific Reports 12(1):1930 (2022)
Allele T
OR 0.35
p 2.0e-13
N 7,055
Large GWAS
East Asian
aspartate aminotransferase measurement
Moon S et al. “The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.” Scientific Reports 9(1):1382 (2019)
Allele T
OR 0.05
p 3.0e-13
N 6,949
Large GWAS
East Asian
hypertension
Choe EK et al. “Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.” Scientific Reports 12(1):1930 (2022)
Allele T
OR 0.32
p 1.0e-8
N 9,742
Large GWAS
East Asian
serum alanine aminotransferase amount
Moon S et al. “The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.” Scientific Reports 9(1):1382 (2019)
Allele T
OR 0.06
p 2.0e-8
N 6,949
Large GWAS
East Asian
About TRAFD1
The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
View all TRAFD1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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