rs150057262
This is a upstream gene variant variant in the NCAN gene.
▶GWAS Catalog Trait Associations (44)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (44)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
omega-3 polyunsaturated fatty acid measurement
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.21
p 1.0e-27
N 115,006
Large GWAS
European
polyunsaturated fatty acid measurement
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.17
p 2.0e-17
N 115,006
Large GWAS
European
docosahexaenoic acid measurement
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.16
p 6.0e-17
N 115,006
Large GWAS
European
Hypercholesterolemia
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.29
p 6.0e-17
N 394,626
Large GWAS
European
type 2 diabetes mellitus
Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)
Allele G
OR —
p 3.0e-14
N 2,535,601
Large GWAS
multi-ancestry
linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] measurement
Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele G
OR 0.31
p 3.0e-13
N 6,136
Large GWAS
European
cholesteryl esters to total lipids in small LDL percentage
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele G
OR 0.16
p 3.0e-12
N 88,329
Large GWAS
European
lipid measurement, blood VLDL cholesterol amount
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.14
p 3.0e-12
N 115,082
Large GWAS
European
high density lipoprotein cholesterol measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele C
OR 0.11
p 4.0e-12
N 136,016
Large GWAS
multi-ancestry
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.12
p 1.0e-9
N 115,082
Large GWAS
European
level of triacylglycerol (56:6) in blood serum
Tabassum R et al. “Lipidome- and Genome-Wide Study to Understand Sex Differences in Circulatory Lipids.” Journal of the American Heart Association 11(19):e027103 (2022)
Allele G
OR 0.34
p 4.0e-12
N 4,642
Large GWAS
European
About NCAN
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]
View all NCAN variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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