rs17030613
This variant is located in the CAPZA1 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
intraocular pressure measurement
Gao XR et al. “Genome-wide association analyses identify new loci influencing intraocular pressure.” Human Molecular Genetics 27(12):2205-2213 (2018)
Allele A
OR 0.12
p 2.0e-12
N 115,486
Large GWAS
European
mean arterial pressure
Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele A
OR 0.34
p 9.0e-11
N 130,777
Large GWAS
multi-ancestry
hypertension
Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele A
OR 0.08
p 1.0e-10
N 50,792
Large GWAS
multi-ancestry
systolic blood pressure
Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele A
OR 0.47
p 3.0e-10
N 130,777
Large GWAS
multi-ancestry
diastolic blood pressure
Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)
Allele C
OR 0.28
p 6.0e-9
N 130,777
Large GWAS
multi-ancestry
Kato N et al. “Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.” Nature Genetics 43(6):531-8 (2011)
Allele C
OR 0.38
p 1.0e-8
N 19,608
Meta-analysisLarge GWAS
East Asian
total cholesterol measurement
Klarin D et al. “Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.” Nature Genetics 50(11):1514-1523 (2018)
Allele A
OR 0.01
p 2.0e-8
N 297,626
Major Consortium StudyLarge GWAS
multi-ancestry
About CAPZA1
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
View all CAPZA1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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