rs17561351

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

platelet volume

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.04

p 6.0e-31

N 394,642

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele G

OR 0.04

p 6.0e-10

N 164,454

Large GWAS

European

apolipoprotein B measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.06

p 4.0e-27

N 354,097

Major Consortium StudyLarge GWAS

multi-ancestry

low density lipoprotein cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.04

p 7.0e-18

N 355,197

Major Consortium StudyLarge GWAS

multi-ancestry

lymphotactin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.08

p 2.0e-15

N 47,745

Large GWAS

European

triglyceride measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.04

p 4.0e-15

N 355,577

Major Consortium StudyLarge GWAS

multi-ancestry

platelet crit

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.04

p 5.0e-14

N 408,112

Large GWAS

European

eosinophil count

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele G

OR 0.03

p 2.0e-11

N 408,112

Large GWAS

European

HbA1c measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.03

p 2.0e-11

N 338,919

Major Consortium StudyLarge GWAS

multi-ancestry

total cholesterol measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.03

p 1.0e-10

N 355,858

Major Consortium StudyLarge GWAS

multi-ancestry

immature platelet count

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele G

OR 0.09

p 2.0e-10

N 36,618

Large GWAS

European

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Research that mentions this SNP (1)

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Haplotype architecture of the Alzheimer's risk in the APOE region via co‐skewness

AssociationN=19,123Alexander M. Kulminski et al.(2020)· Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

This study examined 4960 SNP triples from five genes in the APOE region (BCAM, NECTIN2, TOMM40, APOE, APOC1) in 2789 Alzheimer's disease cases and 16,334 controls using a novel co-skewness metric to identify complex haplotypes associated with AD. The authors identified 1127 significant AD-associated SNP triples, demonstrating that complex multi-SNP haplotypes—which may not include the canonical APOE ε4 or ε2 alleles—play definitive roles in AD predisposition, with the ε4 allele showing strengthened connections to other region alleles and ε2 showing weakened connections in affected subjects.

Traits studied:Alzheimer's disease

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs17561351

GWAS Catalog Trait Associations (10)

platelet volume

apolipoprotein B measurement

low density lipoprotein cholesterol measurement

lymphotactin measurement

triglyceride measurement

platelet crit

eosinophil count

HbA1c measurement

total cholesterol measurement

immature platelet count

Research that mentions this SNP (1)

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