rs2126263
▶GWAS Catalog Trait Associations (21)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (21)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
high density lipoprotein cholesterol measurement
Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)
Allele A
OR 0.15
p 5.0e-39
N 38,000
Large GWAS
South Asian
Choudhury A et al. “Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits.” Nature Communications 13(1):2578 (2022)
Allele A
OR 0.06
p 1.0e-8
N 24,616
Meta-analysisLarge GWAS
Sub-Saharan African
cholesterol:total lipids ratio, intermediate density lipoprotein measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.07
p 3.0e-27
N 136,016
Large GWAS
multi-ancestry
triglycerides:total lipids ratio, intermediate density lipoprotein measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.07
p 8.0e-27
N 136,016
Large GWAS
multi-ancestry
depressive symptom measurement, non-high density lipoprotein cholesterol measurement
Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele A
OR —
β 0.007
p 2.0e-22
N 89,939
Large GWAS
European
docosahexaenoic acid measurement
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele G
OR —
p 7.0e-21
N 239,268
Large GWAS
European
carboxypeptidase B2 amount
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.07
p 1.0e-18
N 47,745
Large GWAS
European
total cholesterol measurement
Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)
Allele A
OR 0.10
p 4.0e-18
N 38,000
Large GWAS
South Asian
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele A
OR 0.07
p 3.0e-15
N 48,057
Large GWAS
Hispanic or Latin American
serum albumin amount
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.06
p 1.0e-17
N 136,016
Large GWAS
multi-ancestry
Harrison S et al. “Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.” Science Advances 7(31) (2021)
Allele A
OR 0.16
p 5.0e-14
N 148,248
Major Consortium StudyLarge GWAS
European
cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement
Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.05
p 1.0e-16
N 136,016
Large GWAS
multi-ancestry
omega-3 polyunsaturated fatty acid measurement
Sun Y et al. “GWAS and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating fatty acids.” Hgg Advances 6(4):100470 (2025)
Allele G
OR —
p 2.0e-15
N 239,268
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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