rs2155219

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

eosinophil count

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.03
p 3.0e-68
N 442,919
Large GWAS
multi-ancestry

Crohn's disease

Liu JZ et al. “Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.” Nature Genetics 47(9):979-986 (2015)
Allele A
OR 1.19
p 6.0e-46
N 20,883
Large GWAS
multi-ancestry

inflammatory bowel disease

Jostins L et al. “Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.” Nature 491(7422):119-24 (2012)
Allele T
OR 1.15
p 4.0e-36
N 34,366
Large GWAS
European

ulcerative colitis

Liu JZ et al. “Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.” Nature Genetics 47(9):979-986 (2015)
Allele T
OR 1.13
p 8.0e-21
N 27,432
Large GWAS
multi-ancestry
Anderson CA et al. “Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.” Nature Genetics 43(3):246-52 (2011)
Allele T
OR 1.13
p 5.0e-16
N 26,405
Meta-analysisLarge GWAS
European

allergic disease

Hinds DA et al. “A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.” Nature Genetics 45(8):907-11 (2013)
Allele T
OR 0.11
p 2.0e-19
N 53,862
Meta-analysisLarge GWAS
European

allergic sensitization measurement

Bønnelykke K et al. “Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.” Nature Genetics 45(8):902-906 (2013)
Allele T
OR 1.18
p 1.0e-18
N 15,845
Meta-analysisLarge GWAS
European

atopic eczema, childhood onset asthma, atopic march

Marenholz I et al. “Meta-analysis identifies seven susceptibility loci involved in the atopic march.” Nature Communications 6:8804 (2015)
Allele T
OR 1.33
p 2.0e-15
N 11,181
Meta-analysisLarge GWAS
European

asthma

Demenais F et al. “Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.” Nature Genetics 50(1):42-53 (2018)
Allele T
OR 0.11
p 3.0e-15
N 127,669
Large GWAS
European

seasonal allergic rhinitis

Ramasamy A et al. “A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.” The Journal of Allergy and Clinical Immunology 128(5):996-1005 (2011)
Allele T
OR 1.22
p 1.0e-8
N 12,347
Meta-analysisLarge GWAS
European

alopecia areata

Betz RC et al. “Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.” Nature Communications 6:5966 (2015)
Allele T
OR 1.21
p 4.0e-8
N 7,565
Meta-analysis
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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