rs2445610
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Graves disease
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele G
OR 0.10
p 2.0e-16
N 2,460,657
Large GWAS
multi-ancestry
Thyroid preparation use measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.07
p 3.0e-16
N 484,308
Large GWAS
multi-ancestry
Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)
Allele G
OR 0.07
p 1.0e-13
N 305,582
Major Consortium StudyLarge GWAS
European
autoimmune thyroid disease
Saevarsdottir S et al. “FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.” Nature 584(7822):619-623 (2020)
Allele A
OR 1.08
p 1.0e-15
N 754,406
Large GWAS
European
Zeng Y et al. “Genetic Associations Between Stress-Related Disorders and Autoimmune Disease.” The American Journal of Psychiatry 180(4):294-304 (2023)
Allele A
OR 0.93
p 3.0e-13
N 376,871
Large GWAS
European
hypothyroidism
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.07
p 5.0e-13
N 394,626
Large GWAS
European
systemic lupus erythematosus
Wang YF et al. “Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups.” Nature Communications 12(1):772 (2021)
Allele G
OR 0.89
p 5.0e-8
N 12,653
Large GWAS
East Asian
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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