rs267734

This is a upstream gene variant variant in the ANXA9 gene.

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cholesteryl ester measurement

Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)

Allele C

OR 0.05

p 4.0e-16

N 88,329

Large GWAS

European

cholesterol in small HDL measurement

Allele C

OR 0.05

p 3.0e-15

N 88,329

Large GWAS

European

free cholesterol in very large HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.02

p 3.0e-15

N 450,015

Large GWAS

multi-ancestry

phospholipids:total lipids ratio

Allele C

OR 0.04

p 2.0e-14

N 88,329

Large GWAS

European

reticulocyte count

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.02

p 2.0e-14

N 394,642

Large GWAS

European

high density lipoprotein cholesterol measurement

Allele C

OR 0.04

p 1.0e-13

N 88,329

Large GWAS

European

reticulocyte amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.02

p 1.0e-13

N 394,642

Large GWAS

European

chronic kidney disease, serum creatinine amount

Köttgen A et al. “New loci associated with kidney function and chronic kidney disease.” Nature Genetics 42(5):376-84 (2010)

Allele C

OR 0.01

p 1.0e-12

N 67,093

Large GWAS

European

phospholipids:total lipids ratio, blood VLDL cholesterol amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele T

OR 0.03

p 5.0e-10

N 114,160

Large GWAS

European

serum creatinine amount, glomerular filtration rate

Pattaro C et al. “Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.” Nature Communications 7:10023 (2016)

Allele T

OR 0.01

p 3.0e-12

N 118,448

Large GWAS

European

About ANXA9

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]

rs267734

GWAS Catalog Trait Associations (10)

cholesteryl ester measurement

cholesterol in small HDL measurement

free cholesterol in very large HDL measurement

phospholipids:total lipids ratio

reticulocyte count

high density lipoprotein cholesterol measurement

reticulocyte amount

chronic kidney disease, serum creatinine amount

phospholipids:total lipids ratio, blood VLDL cholesterol amount

serum creatinine amount, glomerular filtration rate

About ANXA9

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