rs3747973

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GWAS Catalog Trait Associations (17)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

high density lipoprotein cholesterol measurement

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele A

OR 0.02

p 1.0e-19

N 928,679

Large GWAS

multi-ancestry

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele A

OR 0.02

p 4.0e-17

N 1,320,016

Large GWAS

European

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.01

p 3.0e-14

N 450,015

Large GWAS

multi-ancestry

Richardson TG et al. “Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.” Plos Medicine 17(3):e1003062 (2020)

Allele A

OR 0.01

p 3.0e-13

N 403,943

Large GWAS

European

lean body mass

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)

Allele G

OR 0.01

p 1.0e-16

N 337,739

Large GWAS

European

free cholesterol in medium HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 5.0e-16

N 450,015

Large GWAS

multi-ancestry

cholesterol in medium HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 9.0e-16

N 450,015

Large GWAS

multi-ancestry

phospholipids in HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 9.0e-16

N 450,015

Large GWAS

multi-ancestry

total lipids in HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 1.0e-15

N 450,015

Large GWAS

multi-ancestry

apolipoprotein A 1 measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 2.0e-15

N 450,015

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.01

p 3.0e-12

N 394,642

Large GWAS

European

Allele G

OR 0.01

p 1.0e-13

N 393,193

Large GWAS

European

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele G

OR 0.02

p 3.0e-9

N 323,833

Major Consortium StudyLarge GWAS

multi-ancestry

cholesteryl esters in medium HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 2.0e-15

N 450,015

Large GWAS

multi-ancestry

concentration of medium HDL particles measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 2.0e-15

N 450,015

Large GWAS

multi-ancestry

total lipids in medium HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele G

OR 0.01

p 2.0e-15

N 450,015

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs3747973

GWAS Catalog Trait Associations (17)

high density lipoprotein cholesterol measurement

lean body mass

free cholesterol in medium HDL measurement

cholesterol in medium HDL measurement

phospholipids in HDL measurement

total lipids in HDL measurement

apolipoprotein A 1 measurement

cholesteryl esters in medium HDL measurement

concentration of medium HDL particles measurement

total lipids in medium HDL measurement

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