rs3757840

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glucose measurement

Lagou V et al. “GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.” Nature Genetics 55(9):1448-1461 (2023)

Allele T

OR 0.01

p 9.0e-194

N 475,416

Large GWAS

multi-ancestry

type 2 diabetes mellitus

Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)

Allele G

OR 0.04

p 1.0e-16

N 6,710,881

Meta-analysisLarge GWAS

multi-ancestry

metabolic syndrome

Kristiansson K et al. “Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.” Circulation. Cardiovascular Genetics 5(2):242-9 (2012)

Allele A

OR 0.10

p 4.0e-13

N 10,564

Large GWAS

European

triglyceride measurement

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele G

OR 0.02

p 5.0e-12

N 153,950

Large GWAS

East Asian

total cholesterol measurement

Allele G

OR 0.02

p 3.0e-10

N 153,950

Large GWAS

East Asian

osteoarthritis

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)

Allele T

OR 0.98

p 1.0e-8

N 1,962,069

Large GWAS

multi-ancestry

fructosamine measurement

Riveros-Mckay F et al. “An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.” Diabetes 71(2):359-364 (2022)

Allele T

OR 0.01

p 4.0e-8

N 20,731

Large GWAS

European

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Research that mentions this SNP (1)

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Fasting Glucose GWAS Candidate Region Analysis Across Ethnic Groups in the Multiethnic Study of Atherosclerosis (MESA)

AssociationN=5,550Rasmussen-Torvik LJ et al.(2012)· Genetic Epidemiology

This study examined genetic variants associated with fasting glucose from previously identified GWAS loci in four ethnic groups (Caucasian, African American, Hispanic, and Chinese descent) from the Multi-Ethnic Study of Atherosclerosis (MESA). The analysis focused on three gene regions (MTNR1B, GCK, and G6PC2) and found that rs10830963 in MTNR1B and rs4607517 in GCK demonstrated consistent magnitude of association with fasting glucose across ethnic groups (p = 1.29E-12 and p = 1.0E-7, respectively in meta-analysis), with effect sizes ranging from 1.22-1.66 mg/dl and -1.19 to -1.06 mg/dl respectively.

Traits studied:Fasting glucose

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs3757840

GWAS Catalog Trait Associations (7)

glucose measurement

type 2 diabetes mellitus

metabolic syndrome

triglyceride measurement

total cholesterol measurement

osteoarthritis

fructosamine measurement

Research that mentions this SNP (1)

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