rs4409766

▶

GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)

Allele C

OR 0.03

p 6.0e-17

N 158,284

Large GWAS

multi-ancestry

Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)

Allele C

OR —

β 0.029

p 2.0e-12

N 334,487

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 6.0e-12

N 163,835

Large GWAS

East Asian

systolic blood pressure

Lu X et al. “Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.” Human Molecular Genetics 24(3):865-74 (2015)

Allele T

OR 1.24

p 6.0e-17

N 11,816

Large GWAS

East Asian

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.58

p 3.0e-12

N 130,777

Large GWAS

multi-ancestry

diastolic blood pressure

Lu X et al. “Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.” Human Molecular Genetics 24(3):865-74 (2015)

Allele T

OR 0.59

p 6.0e-13

N 11,816

Large GWAS

East Asian

Li C et al. “Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.” Circulation. Cardiovascular Genetics 10(2):e001527 (2017)

Allele T

OR 0.40

p 8.0e-9

N 18,422

Meta-analysisLarge GWAS

multi-ancestry

hypertension

Lu X et al. “Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.” Human Molecular Genetics 24(3):865-74 (2015)

Allele T

OR —

p 7.0e-13

N 9,469

Large GWAS

East Asian

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.09

p 4.0e-10

N 50,792

Large GWAS

multi-ancestry

mean arterial pressure

Li C et al. “Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.” Circulation. Cardiovascular Genetics 10(2):e001527 (2017)

Allele T

OR 0.54

p 1.0e-11

N 18,422

Meta-analysisLarge GWAS

multi-ancestry

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.33

p 3.0e-8

N 130,777

Large GWAS

multi-ancestry

pulse pressure measurement

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele T

OR 0.38

p 2.0e-11

N 130,777

Large GWAS

multi-ancestry

angina pectoris

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.11

p 3.0e-10

N 608,573

Large GWAS

multi-ancestry

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)

Allele C

OR 0.01

p 2.0e-8

N 2,083,151

Large GWAS

European

▶

Research that mentions this SNP (1)

▶

A Comprehensive Family-Based Replication Study of Schizophrenia Genes

AssociationN=28,251Karolina A. Aberg et al.(2013)· JAMA Psychiatry

This comprehensive family-based replication study tested 8,107 SNPs in 6,298 individuals (3,286 schizophrenia cases) from 1,811 nuclear families, following a meta-analysis of 18 schizophrenia GWAS studies. The study replicated major findings in TCF4 (P=2.53×10⁻¹⁰) and NOTCH4 (P=3.16×10⁻⁷), and identified novel susceptibility loci including POM121L2 (P=3.51×10⁻⁷), AS3MT (P=9.01×10⁻⁷), CNNM2 (P=6.07×10⁻⁷), and NT5C2 (P=4.09×10⁻⁷). Pathway analyses revealed significant enrichment in neuronal function (axonal guidance, neuronal systems, L1 cell adhesion) and immune system pathways (antigen processing, T-cell adhesion molecules).

Traits studied:Schizophrenia

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs4409766

GWAS Catalog Trait Associations (8)

body mass index

systolic blood pressure

diastolic blood pressure

hypertension

mean arterial pressure

pulse pressure measurement

angina pectoris

wellbeing measurement

Research that mentions this SNP (1)

Community Wiki

Comments