rs4455710

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cutaneous squamous cell carcinoma

Choquet H et al. “Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma.” Communications Biology 7(1):33 (2024)

Allele T

OR 1.18

p 2.0e-21

N 778,893

Meta-analysisLarge GWAS

European

Sarin KY et al. “Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma.” Nature Communications 11(1):820 (2020)

Allele T

OR 0.14

p 6.0e-21

N 699,198

Meta-analysisLarge GWAS

European

squamous cell carcinoma

Asgari MM et al. “Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma.” The Journal of Investigative Dermatology 136(5):930-937 (2016)

Allele T

OR 1.17

p 2.0e-18

N 61,457

Large GWAS

European

actinic keratosis

Kim Y et al. “Genome-wide association study of actinic keratosis identifies new susceptibility loci implicated in pigmentation and immune regulation pathways.” Communications Biology 5(1):386 (2022)

Allele T

OR 1.08

p 2.0e-11

N 92,240

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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