rs56084168

This is a regulatory region variant variant in the BAIAP2 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele T
OR 8.20
p 3.0e-16
N 449,484
Meta-analysisLarge GWAS
European
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele T
OR 7.18
p 7.0e-13
N 380,506
Large GWAS
European
Kim Y et al. “Genetic and neural bases of the neuroticism general factor.” Biological Psychology 184:108692 (2023)
Allele T
OR 0.01
p 7.0e-12
N 380,000
Large GWAS
Nagel M et al. “Genome-wide association study of the sensitivity to environmental stress and adversity neuroticism cluster.” Acta Psychiatrica Scandinavica 141(5):476-478 (2020)
Allele T
OR —
β 0.020
p 2.0e-9
N 351,827
Large GWAS
European

neurotic disorder

Cai N et al. “Minimal phenotyping yields genome-wide association signals of low specificity for major depression.” Nature Genetics 52(4):437-447 (2020)
Allele T
OR 0.01
p 1.0e-10
N 274,107
Large GWAS
European

Anxiety

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele T
OR 0.02
p 2.0e-10
N 348,219
Meta-analysisLarge GWAS
European

feeling tense measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele T
OR 5.47
p 5.0e-8
N 371,318
Large GWAS
European

About BAIAP2

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

View all BAIAP2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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