rs576269767

This variant is located in the RELB gene.

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GWAS Catalog Trait Associations (32)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.38

p 3.0e-29

N 115,082

Large GWAS

European

cholesterol:total lipids ratio, intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.36

p 6.0e-27

N 115,082

Large GWAS

European

triglycerides:total lipids ratio, intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.35

p 8.0e-26

N 115,082

Large GWAS

European

cholesteryl ester measurement, intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.34

p 1.0e-24

N 115,082

Large GWAS

European

total cholesterol measurement, intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.34

p 2.0e-23

N 115,082

Large GWAS

European

free cholesterol:total lipids ratio, blood VLDL cholesterol amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.32

p 2.0e-22

N 115,082

Large GWAS

European

cholesteryl esters:total lipids ratio, blood VLDL cholesterol amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.32

p 3.0e-22

N 115,082

Large GWAS

European

phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.32

p 8.0e-22

N 115,082

Large GWAS

European

intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.32

p 2.0e-20

N 115,082

Large GWAS

European

cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.31

p 6.0e-20

N 115,082

Large GWAS

European

About RELB

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

rs576269767

GWAS Catalog Trait Associations (32)

cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

cholesterol:total lipids ratio, intermediate density lipoprotein measurement

triglycerides:total lipids ratio, intermediate density lipoprotein measurement

cholesteryl ester measurement, intermediate density lipoprotein measurement

total cholesterol measurement, intermediate density lipoprotein measurement

free cholesterol:total lipids ratio, blood VLDL cholesterol amount

cholesteryl esters:total lipids ratio, blood VLDL cholesterol amount

phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

intermediate density lipoprotein measurement

cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

About RELB

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